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| Verfasst von: | Tektonidis, Marco [VerfasserIn]  |
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| | Hatzikirou, Haralambos [VerfasserIn] |
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| | Chauvière, Arnaud [VerfasserIn] |
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| | Simon, Matthias [VerfasserIn] |
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| | Schaller, Karl [VerfasserIn] |
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| | Deutsch, Andreas [VerfasserIn] |
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| Titel: | Identification of intrinsic in vitro cellular mechanisms for glioma invasion |
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| Verf.angabe: | Marco Tektonidis, Haralambos Hatzikirou, Arnaud Chauvière, Matthias Simon, Karl Schaller, Andreas Deutsch |
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| E-Jahr: | 2011 |
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| Jahr: | 29 July 2011 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 27.10.2022 |
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| Titel Quelle: | Enthalten in: Journal of theoretical biology |
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| Ort Quelle: | Amsterdam : Elsevier Ltd., 1961 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 287(2011), Seite 131-147 |
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| ISSN Quelle: | 1095-8541 |
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| Abstract: | Invasion of malignant glioma is a highly complex phenomenon involving molecular and cellular processes at various spatio-temporal scales, whose precise interplay is still not fully understood. In order to identify the intrinsic cellular mechanisms of glioma invasion, we study an in vitro culture of glioma cells. By means of a computational approach, based on a cellular automaton model, we compare simulation results to the experimental data and deduce cellular mechanisms from microscopic and macroscopic observables (experimental data). For the first time, it is shown that the migration/proliferation dichotomy plays a central role in the invasion of glioma cells. Interestingly, we conclude that a diverging invasive zone is a consequence of this dichotomy. Additionally, we observe that radial persistence of glioma cells in the vicinity of dense areas accelerates the invasion process. We argue that this persistence results from a cell-cell repulsion mechanism. If glioma cell behavior is regulated through a migration/proliferation dichotomy and a self-repellent mechanism, our simulations faithfully reproduce all the experimental observations. |
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| DOI: | doi:10.1016/j.jtbi.2011.07.012 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jtbi.2011.07.012 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0022519311003626 |
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| | DOI: https://doi.org/10.1016/j.jtbi.2011.07.012 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cell migration/proliferation |
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| | Cellular automaton model |
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| | Glioma invasion |
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| | Go-or-Grow |
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| K10plus-PPN: | 1820166325 |
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| Verknüpfungen: | → Zeitschrift |
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Identification of intrinsic in vitro cellular mechanisms for glioma invasion / Tektonidis, Marco [VerfasserIn]; 29 July 2011 (Online-Ressource)
