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Verfasst von:Filipović, Dragana [VerfasserIn]   i
 Zlatković, J. [VerfasserIn]   i
 Inta, Dragos [VerfasserIn]   i
 Bjelobaba, I. [VerfasserIn]   i
 Stojiljkovic, M. [VerfasserIn]   i
 Gass, Peter [VerfasserIn]   i
Titel:Chronic isolation stress predisposes the frontal cortex but not the hippocampus to the potentially detrimental release of cytochrome c from mitochondria and the activation of caspase-3
Verf.angabe:D. Filipović, J. Zlatković, D. Inta, I. Bjelobaba, M. Stojiljkovic and P. Gass
E-Jahr:2011
Jahr:8 June 2011
Umfang:10 S.
Fussnoten:Gesehen am 27.10.2022
Titel Quelle:Enthalten in: Journal of neuroscience research
Ort Quelle:New York, NY [u.a.] : Wiley-Liss, 1975
Jahr Quelle:2011
Band/Heft Quelle:89(2011), 9 vom: Sept., Seite 1461-1470
ISSN Quelle:1097-4547
Abstract:Mitochondria are central integrators and transducers of proapoptotic signals for neuronal apoptosis. The tumor suppressor protein p53 can trigger apoptosis independently of its transcriptional activity, through subcellular translocation of cytochrome c and caspase activation. To define better the proapoptotic role of p53 under various stress conditions, we investigated the protein levels of p53 and cytochrome c in mitochondrial and cytosolic fractions, as well as caspase-3 activation and apoptosis, in the prefrontal cortex and hippocampus of male Wistar rats subjected to acute, chronic, or combined stressors. Mitochondrial p53 can suppress the antioxidant enzyme MnSOD, so its activity was also determined. In the prefrontal cortex, but not in hippocampus, increased protein levels of p53 were found in mitochondria, leading to cytochrome c release into cytoplasm, activation of caspase-3, and apoptotic cell death following combined stressors. Decreased mitochondrial MnSOD activity following combined stressors in both brain structures indicated a state of oxidative stress. This suggests that chronic isolation stress compromises mitochondrial MnSOD activity in both the prefrontal cortex and the hippocampus but likely results in mitochondrial-triggered proapoptotic signaling mediated by a transcription-independent p53 mechanism only in the prefrontal cortex. Thus, our data demonstrate a tissue-specific (prefrontal cortex vs. hippocampus) response to applied stressors. © 2011 Wiley-Liss, Inc.
DOI:doi:10.1002/jnr.22687
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/jnr.22687
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jnr.22687
 DOI: https://doi.org/10.1002/jnr.22687
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:MnSOD
 p53
 proapoptotic proteins
 rat brain
 stress
K10plus-PPN:1820190145
Verknüpfungen:→ Zeitschrift

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