| |  Online-Ressource |
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| Verfasst von: | Tamura, Yumi [VerfasserIn]  |
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| | Yamane, Keita [VerfasserIn] |
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| | Kawano, Yohei [VerfasserIn] |
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| | Bullinger, Lars [VerfasserIn] |
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| | Wirtz, Tristan [VerfasserIn] |
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| | Weber, Timm [VerfasserIn] |
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| | Sander, Sandrine [VerfasserIn] |
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| | Ohki, Shun [VerfasserIn] |
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| | Kitajima, Yasuo [VerfasserIn] |
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| | Okada, Satoshi [VerfasserIn] |
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| | Rajewsky, Klaus [VerfasserIn] |
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| | Yasuda, Tomoharu [VerfasserIn] |
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| Titel: | Concomitant cytotoxic effector differentiation of CD4+ and CD8+ T Cells in response to EBV-infected B cells |
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| Verf.angabe: | Yumi Tamura, Keita Yamane, Yohei Kawano, Lars Bullinger, Tristan Wirtz, Timm Weber, Sandrine Sander, Shun Ohki, Yasuo Kitajima, Satoshi Okada, Klaus Rajewsky and Tomoharu Yasuda |
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| E-Jahr: | 2022 |
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| Jahr: | 25 August 2022 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 31.10.2022 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 14(2022), 17 vom: Aug., Artikel-ID 4118, Seite 1-16 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Most people infected by EBV acquire specific immunity, which then controls latent infection throughout their life. Immune surveillance of EBV-infected cells by cytotoxic CD4+ T cells has been recognized; however, the molecular mechanism of generating cytotoxic effector T cells of the CD4+ subset remains poorly understood. Here we compared phenotypic features and the transcriptome of EBV-specific effector-memory CD4+ T cells and CD8+ T cells in mice and found that both T cell types show cytotoxicity and, to our surprise, widely similar gene expression patterns relating to cytotoxicity. Similar to cytotoxic CD8+ T cells, EBV-specific cytotoxic CD4+ T cells from human peripheral blood expressed T-bet, Granzyme B, and Perforin and upregulated the degranulation marker, CD107a, immediately after restimulation. Furthermore, T-bet expression in cytotoxic CD4+ T cells was highly correlated with Granzyme B and Perforin expression at the protein level. Thus, differentiation of EBV-specific cytotoxic CD4+ T cells is possibly controlled by mechanisms shared by cytotoxic CD8+ T cells. T-bet-mediated transcriptional regulation may explain the similarity of cytotoxic effector differentiation between CD4+ T cells and CD8+ T cells, implicating that this differentiation pathway may be directed by environmental input rather than T cell subset. |
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| DOI: | doi:10.3390/cancers14174118 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/cancers14174118 |
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| | Volltext: https://www.mdpi.com/2072-6694/14/17/4118 |
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| | DOI: https://doi.org/10.3390/cancers14174118 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CD107a |
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| | CD4<sup>+</sup> CTL |
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| | Eomes |
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| | Epstein-Barr virus |
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| | Granzyme B |
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| | LMP1 |
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| | LMP2A |
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| | lymphoblastoid cell line |
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| | Perforin |
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| | T-bet |
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| K10plus-PPN: | 1820359255 |
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| Verknüpfungen: | → Zeitschrift |
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Concomitant cytotoxic effector differentiation of CD4+ and CD8+ T Cells in response to EBV-infected B cells / Tamura, Yumi [VerfasserIn]; 25 August 2022 (Online-Ressource)
