| |  Online-Ressource |
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| Verfasst von: | Li, Xiangwei [VerfasserIn]  |
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| | Delerue, Thomas [VerfasserIn] |
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| | Schöttker, Ben [VerfasserIn] |
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| | Holleczek, Bernd [VerfasserIn] |
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| | Grill, Eva [VerfasserIn] |
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| | Peters, Annette [VerfasserIn] |
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| | Waldenberger, Melanie [VerfasserIn] |
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| | Thorand, Barbara [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| Titel: | Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults |
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| Verf.angabe: | Xiangwei Li, Thomas Delerue, Ben Schöttker, Bernd Holleczek, Eva Grill, Annette Peters, Melanie Waldenberger, Barbara Thorand & Hermann Brenner |
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| E-Jahr: | 2022 |
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| Jahr: | 07 September 2022 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 02.11.2022 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 13(2022), Artikel-ID 5269, Seite 1-11 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci. Using LASSO regression, 20 CpGs are selected to derive a DNAm based algorithm for predicting frailty, the epigenetic frailty risk score (eFRS). The eFRS exhibits strong associations with frailty at baseline and after up to five-years of follow-up independently of established frailty risk factors. These associations are confirmed in another independent population-based cohort study, the KORA-Age study, conducted in older adults. In conclusion, we identify 65 CpGs as frailty-related loci, of which 20 CpGs are used to calculate the eFRS with predictive performance for frailty over long-term follow-up. |
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| DOI: | doi:10.1038/s41467-022-32893-x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-022-32893-x |
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| | Volltext: https://www.nature.com/articles/s41467-022-32893-x |
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| | DOI: https://doi.org/10.1038/s41467-022-32893-x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | DNA methylation |
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| | Epidemiology |
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| | Geriatrics |
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| | Predictive markers |
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| K10plus-PPN: | 182051630X |
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| Verknüpfungen: | → Zeitschrift |
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Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults / Li, Xiangwei [VerfasserIn]; 07 September 2022 (Online-Ressource)
