| Online-Ressource |
Verfasst von: | Thomas, Bettina C. [VerfasserIn]  |
| Zimmermann, Stefan [VerfasserIn]  |
| Völcker, Hans Eberhard [VerfasserIn]  |
| Auffarth, Gerd U. [VerfasserIn]  |
| Dithmar, Stefan [VerfasserIn]  |
Titel: | Severe Arthrographis kalrae keratomycosis in an immunocompetent Patient |
Verf.angabe: | Bettina C. Thomas, MD, Stefan Zimmermann, MD, Hans-Eberhard Völcker, MD, Gerd U. Auffarth, MD, and Stefan Dithmar, MD |
Jahr: | 2011 |
Umfang: | 3 S. |
Fussnoten: | Gesehen am 02.11.2022 |
Titel Quelle: | Enthalten in: Cornea |
Ort Quelle: | Philadelphia, Pa. : Lippincott, Williams & Wilkins, 1982 |
Jahr Quelle: | 2011 |
Band/Heft Quelle: | 30(2011), 3 vom: März, Seite 364-366 |
ISSN Quelle: | 1536-4798 |
Abstract: | Purpose: - To describe a severe case of keratomycosis caused by Arthrographis kalrae requiring repeated keratoplasty. - Methods: - A 42-year-old otherwise healthy soft contact lens wearer developed a unilateral central corneal ulcer. Treatment with topical and systemic voriconazole is described. - Results: - Repeated microbiological testing of ocular swabs (culture) initially yielded Candida albicans. Under treatment with topical clotrimazole, the ulcer progressed, and a corneal perforation required a keratoplasty à chaud. For prophylaxis, the patient received fluconazole systemically and continuous topical clotrimazole. However, in 2 weeks time, the mycotic infiltrates penetrated the corneal transplant and led to a second keratoplasty only 1 month after the first one. In the meantime, the microbiological analysis of the first keratoplasty revealed A. kalrae, which was sensitive to voriconazole. High-dose serum level-controlled systemic voriconazole and topical voriconazole were able to stabilize, but not eliminate the infection. About 1 year after the start of the voriconazole therapy, treatment had to be discontinued because of side effects. Mycotic infiltrates increased, and even an intracameral voriconazole injection could not prevent a third and a fourth keratoplasty. - Conclusions: - Ocular infection with A. kalrae is very rare. The microbiological differentiation of A. kalrae can be difficult. Because a broad spectrum of fungi is sensitive to voriconazole, the early topical and possibly systemic treatment is a reasonable therapeutic option when a mycotic infection of the eye is suspected, even before the causative fungus is identified. |
DOI: | doi:10.1097/ICO.0b013e3181eadeb9 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1097/ICO.0b013e3181eadeb9 |
| Volltext: https://journals.lww.com/corneajrnl/Fulltext/2011/03000/Severe_Arthrographis_kalrae_Keratomycosis_in_an.23.aspx |
| DOI: https://doi.org/10.1097/ICO.0b013e3181eadeb9 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1820521516 |
Verknüpfungen: | → Zeitschrift |
Severe Arthrographis kalrae keratomycosis in an immunocompetent Patient / Thomas, Bettina C. [VerfasserIn]; 2011 (Online-Ressource)