Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

• Verfasst von: Vrančić, Christian [VerfasserIn]
• Verfasst von: Fomichova, Anna [VerfasserIn]
• Verfasst von: Gretz, Norbert [VerfasserIn]
• Verfasst von: Herrmann, Carina [VerfasserIn]
• Verfasst von: Neudecker, Sabine [VerfasserIn]
• Verfasst von: Pucci, Annemarie [VerfasserIn]
• Verfasst von: Petrich, Wolfgang [VerfasserIn]
• Titel: Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro
• Verf.angabe: Christian Vrančić, Anna Fomichova, Norbert Gretz, Carina Herrmann, Sabine Neudecker, Annemarie Pucci and Wolfgang Petrich
• E-Jahr: 2011
• Jahr: 27 January 2011
• Umfang: 7 S.
• Fussnoten: Gesehen am 03.11.2022
• Titel Quelle: Enthalten in: The analyst
• Ort Quelle: Cambridge : Soc., 1876
• Jahr Quelle: 2011
• Band/Heft Quelle: 136(2011), 6, Seite 1192-1198
• ISSN Quelle: 1364-5528
• DOI: doi:10.1039/C0AN00537A
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopy in vitro. - 2011
• K10plus-PPN: 1820654222

Abstract

The continuous surveillance of glucose concentration reduces short-term risks and long-term complications for people with diabetes mellitus, a disorder of glucose metabolism. As a first step towards the continuous monitoring of glucose, reagent-free transmission spectroscopy in the mid-infrared region has been carried out in vitro using a quantum cascade laser and an optical silver halide fiber. A 30 μm gap in the fiber allowed for transmission spectroscopy of aqueous glucose solutions at a wavelength of 9.69 μm, which is specific to a molecular vibration of glucose. A noise-equivalent concentration as low as 4 mg/dL was achieved at an average power of 1.8 mW and an integration time of 50 s. This is among the most precise of glucose measurements using mid-infrared spectroscopy. Even with the very low average laser power of 0.07 mW the sensitivity of previous results (using a fiber optical evanescent field analysis) has been improved upon by almost one order of magnitude. Finally, the impact of potentially interfering substances such as other carbohydrates was analyzed.