| |  Online-Ressource |
|---|
| Verfasst von: | Tilkorn, Daniel-Johannes [VerfasserIn]  |
|---|
| | Daigeler, Adrien [VerfasserIn] |
|---|
| | Stricker, Ingo [VerfasserIn] |
|---|
| | Schaffran, Angela [VerfasserIn] |
|---|
| | Schmitz, Inge [VerfasserIn] |
|---|
| | Steinstraesser, Lars [VerfasserIn] |
|---|
| | Hauser, Joerg [VerfasserIn] |
|---|
| | Ring, Andrej [VerfasserIn] |
|---|
| | Steinau, Hans-Ulrich [VerfasserIn] |
|---|
| | Al-Benna, Sammy [VerfasserIn] |
|---|
| Titel: | Establishing efficient xenograft models with intrinsic vascularisation for growing primary human low-grade sarcomas |
|---|
| Verf.angabe: | Daniel Tilkorn, Adrien Daigeler, Ingo Stricker, Angela Schaffran, Inge Schmitz, Lars Steinstraesser, Joerg Hauser, Andrej Ring, Hans-Ulrich Steinau and Sammy Al-Benna |
|---|
| Jahr: | 2011 |
|---|
| Umfang: | 6 S. |
|---|
| Fussnoten: | Gesehen am 03.11.2022 |
|---|
| Titel Quelle: | Enthalten in: Anticancer research |
|---|
| Ort Quelle: | Attiki, 2004 |
|---|
| Jahr Quelle: | 2011 |
|---|
| Band/Heft Quelle: | 31(2011), 12, Seite 4061-4066 |
|---|
| ISSN Quelle: | 1791-7530 |
|---|
| Abstract: | Background: There are no xenograft models of low-grade soft tissue sarcoma. Transplant survival remains an obstacle in sarcoma xenograft models and is attributed to post-transplantation hypoxia. Models with an intrinsic tissue - engineered vascular supply may overcome this obstacle. The aim of this study was to establish a novel xenograft model of primary human low grade soft tissue sarcoma. Materials and Methods: Primary low-grade liposarcoma fragments were transplanted into a silicon chamber, placed around the superficial epigastric vessels in athymic nude mice. Xenograft samples were assessed histologically (light/electron microscopy and immunohistochemistry for S100). Results: All xenotransplants of low grade primary soft tissue liposarcoma (n=4) engrafted, led to the development of solid tumours in mice. Histological and immunohistochemical staining confirmed the xenografts as being well-differentiated liposarcomas identical to the original tumor tissue. Conclusion: Successful transplantation of human low-grade liposarcoma tissue in mice was established for the first time using a model with an intrinsic vascular supply. |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://ar.iiarjournals.org/content/31/12/4061 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Athymic mice |
|---|
| | low-grade liposarcoma |
|---|
| | soft tissue sarcoma |
|---|
| | vascularisation |
|---|
| | xenograft |
|---|
| K10plus-PPN: | 1820702561 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Establishing efficient xenograft models with intrinsic vascularisation for growing primary human low-grade sarcomas / Tilkorn, Daniel-Johannes [VerfasserIn]; 2011 (Online-Ressource)
