Prospective comparison of hypofractionated versus normofractionated intensity-modulated radiotherapy in breast cancer

• Verfasst von: Sarria, Gustavo R. [VerfasserIn]
• Verfasst von: Welzel, Grit [VerfasserIn]
• Verfasst von: Polednik, Martin [VerfasserIn]
• Verfasst von: Wenz, Frederik [VerfasserIn]
• Verfasst von: Abo-Madyan, Yasser [VerfasserIn]
• Titel: Prospective comparison of hypofractionated versus normofractionated intensity-modulated radiotherapy in breast cancer
• Titelzusatz: late toxicity results of the non-inferiority KOSIMA Trial (ARO2010-3)
• Verf.angabe: Gustavo R. Sarria, Grit Welzel, Martin Polednik, Frederik Wenz and Yasser Abo-Madyan
• E-Jahr: 2022
• Jahr: 05 May 2022
• Umfang: 8 S.
• Fussnoten: Gesehen am 04.11.2022
• Titel Quelle: Enthalten in: Frontiers in oncology
• Ort Quelle: Lausanne : Frontiers Media, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022) vom: Mai, Artikel-ID 824891, Seite 1-8
• ISSN Quelle: 2234-943X
• DOI: doi:10.3389/fonc.2022.824891
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1820779378
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

PurposeTo compare the late toxicity profile of hypofractionation and normofractionation for whole-breast radiotherapy in breast cancer (BC) patients after conserving surgery.MethodsSixty-year-old or older patients with pTis-pT3, pN0-pN1a, M0 BC were recruited and stratified to hypofractionated (arm R-HF) or normofractionated (arm L-NF) intensity-modulated radiotherapy (IMRT), for right- and left-sided BC, respectively, in this single-center, non-randomized, non-inferiority trial. A boost was allowed if indicated. The primary outcome was the cumulative percentage of patients developing grade III fibrosis, grade I telangiectasia, and/or grade II hyperpigmentation after 2 years, with a pre-specified non-inferiority margin of 15% increase from an expected 2-year toxicity rate of 20%.ResultsThe Median follow-up was 4.93 (0.57-8.65) years for R-HF and 5.02 (0.65-8.72) years for L-NF (p=0.236). The median age was 68 (60-83 and 60-80) years, respectively. In total, 226 patients were recruited (107 for R-HF and 119 for L-NF), with 100 and 117 patients suitable for assessment, respectively. A boost was delivered in 51% and 53% of each arm, respectively. Median PTV volumes were 1013.6 (273-2805) cm3 (R-HF) and 1058.28 (315-2709) cm3 (L-NF, p=0.591). The 2-year primary endpoint rate was 6.1% (95% CI 1.3-11.7, n=5 of 82) and 13.3% (95% CI 7-20.2, n=14 of 105), respectively (absolute difference -7.2%, one-sided 95% CI ∞ to -0.26, favoring R-HF). No local recurrence-free- or overall-survival differences were found.ConclusionIn this prospective non-randomized study, hypofractionation did not have higher toxicity than normofractionated whole-breast IMRT.