Response inhibition or salience detection in the right ventrolateral prefrontal cortex?

• Verfasst von: Walther, Stephan [VerfasserIn]
• Verfasst von: Friederich, Hans-Christoph [VerfasserIn]
• Verfasst von: Stippich, Christoph [VerfasserIn]
• Verfasst von: Weisbrod, Matthias [VerfasserIn]
• Verfasst von: Kaiser, Stefan [VerfasserIn]
• Titel: Response inhibition or salience detection in the right ventrolateral prefrontal cortex?
• Verf.angabe: Stephan Walther, Hans-Christoph Friederich, Christoph Stippich, Matthias Weisbrod and Stefan Kaiser
• Jahr: 2011
• Umfang: 5 S.
• Fussnoten: Gesehen am 07.11.2022
• Titel Quelle: Enthalten in: Neuroreport
• Ort Quelle: London : Lippincott Williams & Wilkins, 1990
• Jahr Quelle: 2011
• Band/Heft Quelle: 22(2011), 15, Seite 778-782
• ISSN Quelle: 1473-558X
• DOI: doi:10.1097/WNR.0b013e32834af670
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1820814580

Abstract

This study addresses the question of whether frontal activation in response-inhibition tasks is specifically associated with the suppression of a motor response. An alternative model suggests a role in the detection of behaviorally relevant or salient events. For this purpose, we used functional MRI with an auditory go/no-go paradigm. This paradigm allowed the disentangling of inhibition-related from salience-related effects, which were associated with different frontal regions. Importantly, the right ventrolateral prefrontal cortex consistently showed sensitivity for salience but not for inhibition requirements. This reflects a more general salience-detection mechanism, which is not specific for response-inhibition tasks.