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| Verfasst von: | Altay, Lebriz [VerfasserIn]  |
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| | Lemke, Julia [VerfasserIn] |
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| | Schröder-Braunstein, Jutta [VerfasserIn] |
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| | Gietzelt, Caroline [VerfasserIn] |
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| | Sitnilska, Vasilena [VerfasserIn] |
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| | Schaub, Friederike [VerfasserIn] |
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| | Cursiefen, Claus [VerfasserIn] |
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| | Enders, Philip [VerfasserIn] |
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| | Fauser, Sascha [VerfasserIn] |
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| Titel: | Ocular and systemic complement activation during anti-vascular endothelial growth factor treatment and age-related eye disease study 2 dietary supplementation in neovascular age-related macular degeneration |
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| Verf.angabe: | Lebriz Altay, Julia Lemke, Jutta Schroeder-Braunstein, Caroline Gietzelt, Vasilena Sitnilska, Friederike Schaub, Claus Cursiefen, Philip Enders, Sascha Fauser |
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| E-Jahr: | 2022 |
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| Jahr: | JUN 2022 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 10.11.2022 |
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| Titel Quelle: | Enthalten in: Ophthalmologica |
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| Ort Quelle: | Basel : Karger, 1899 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 245(2022), 3, Seite 258-264 |
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| ISSN Quelle: | 1423-0267 |
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| Abstract: | Purpose: The aim of this study was to investigate the influence of dietary supplementation using Age-Related Eye Disease Study 2 (AREDS2) on complement activation in patients with neovascular age-related macular degeneration (nAMD) under ongoing treatment. Methods: In this prospective, single-center, controlled, open-label investigator-initiated trial, eligible nAMD patients were randomized at a ratio of 1:1 in 2 groups: those with and without dietary AREDS2 supplementation for 4 weeks. Zinc, plasma, and aqueous humor (AH) complement levels were quantified via enzyme-linked immunosorbent assays. Results: Fifty of 62 enrolled patients completed the trial (AREDS2 n = 27, controls n = 23). Systemic zinc and complement levels were not different at baseline between the 2 groups (p > 0.1). At the final visit, systemic zinc levels were significantly higher in the AREDS2 group (10.16 +/- 2.08 mu mol/L; 8.66 +/- 1.17 mu mol/L; p = 0.007), whereas systemic and AH complement levels were not different (p > 0.1). In both groups, no significant change was observed in systemic levels of C3, C3a, FH, FI, and sC5b-9 (p > 0.1). Only systemic complement component Ba showed an increase from baseline to the end visit (p = 0.01). This increase was higher in the control group (p = 0.02) than in the AREDS2 group (p = 0.23). Conclusions: Short-term dietary AREDS2 supplementation leads to a significant increase in systemic zinc levels without any influence on complement activation levels. |
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| DOI: | doi:10.1159/000516885 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1159/000516885 |
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| | Volltext: https://www.karger.com/Article/Abstract/516885 |
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| | DOI: https://doi.org/10.1159/000516885 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Age-related eye disease study 2 |
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| | antioxidants |
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| | association |
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| | beta-carotene |
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| | cfh |
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| | Complement activation |
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| | drusen |
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| | genotypes |
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| | inflammation |
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| | Neovascular age-related macular degeneration |
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| | zinc |
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| | Zinc |
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| K10plus-PPN: | 1821587677 |
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| Verknüpfungen: | → Zeitschrift |
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Ocular and systemic complement activation during anti-vascular endothelial growth factor treatment and age-related eye disease study 2 dietary supplementation in neovascular age-related macular degeneration / Altay, Lebriz [VerfasserIn]; JUN 2022 (Online-Ressource)
