| |  Online-Ressource |
|---|
| Verfasst von: | Reinscheid, Matthias [VerfasserIn]  |
|---|
| | Luxenburger, Hendrik [VerfasserIn] |
|---|
| | Karl, Vivien [VerfasserIn] |
|---|
| | Graeser, Anne [VerfasserIn] |
|---|
| | Giese, Sebastian [VerfasserIn] |
|---|
| | Ciminski, Kevin [VerfasserIn] |
|---|
| | Reeg, David B. [VerfasserIn] |
|---|
| | Oberhardt, Valerie [VerfasserIn] |
|---|
| | Röhlen, Natascha [VerfasserIn] |
|---|
| | Lang-Meli, Julia [VerfasserIn] |
|---|
| | Heim, Kathrin [VerfasserIn] |
|---|
| | Gross, Nina [VerfasserIn] |
|---|
| | Baum, Christina [VerfasserIn] |
|---|
| | Rieg, Siegbert [VerfasserIn] |
|---|
| | Speer, Claudius [VerfasserIn] |
|---|
| | Emmerich, Florian [VerfasserIn] |
|---|
| | Breisinger, Susanne [VerfasserIn] |
|---|
| | Steinmann, Daniel [VerfasserIn] |
|---|
| | Bengsch, Bertram [VerfasserIn] |
|---|
| | Böttler, Tobias [VerfasserIn] |
|---|
| | Kochs, Georg [VerfasserIn] |
|---|
| | Schwemmle, Martin [VerfasserIn] |
|---|
| | Thimme, Robert [VerfasserIn] |
|---|
| | Neumann-Haefelin, Christoph [VerfasserIn] |
|---|
| | Hofmann, Maike [VerfasserIn] |
|---|
| Titel: | COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation |
|---|
| Verf.angabe: | Matthias Reinscheid, Hendrik Luxenburger, Vivien Karl, Anne Graeser, Sebastian Giese, Kevin Ciminski, David B. Reeg, Valerie Oberhardt, Natascha Roehlen, Julia Lang-Meli, Kathrin Heim, Nina Gross, Christina Baum, Siegbert Rieg, Claudius Speer, Florian Emmerich, Susanne Breisinger, Daniel Steinmann, Bertram Bengsch, Tobias Boettler, Georg Kochs, Martin Schwemmle, Robert Thimme, Christoph Neumann-Haefelin, Maike Hofmann |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | 08 August 2022 |
|---|
| Umfang: | 11 S. |
|---|
| Fussnoten: | Gesehen am 11.11.2022 |
|---|
| Titel Quelle: | Enthalten in: Nature Communications |
|---|
| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 13(2022), Artikel-ID 4631, Seite 1-11 |
|---|
| ISSN Quelle: | 2041-1723 |
|---|
| Abstract: | Immunization with two mRNA vaccine doses elicits robust spike-specific CD8+ T cell responses, but reports of waning immunity after COVID-19 vaccination prompt the introduction of booster vaccination campaigns. However, the effect of mRNA booster vaccination on the spike-specific CD8+ T cell response remains unclear. Here we show that spike-specific CD8+ T cells are activated and expanded in all analyzed individuals receiving the 3rd and 4th mRNA vaccine shots. This CD8+ T cell boost response is followed by a contraction phase and lasts only for about 30-60 days. The spike-specific CD8+ T memory stem cell pool is not affected by the 3rd vaccination. Both 4th vaccination and breakthrough infections with Delta and Omicron rapidly reactivate CD8+ T memory cells. In contrast, neutralizing antibody responses display little boost effect towards Omicron. Thus, COVID-19 mRNA booster vaccination elicits a transient T effector cell response while long-term spike-specific CD8+ T cell immunity is conserved to mount robust memory recall targeting emerging variants of concern. |
|---|
| DOI: | doi:10.1038/s41467-022-32324-x |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext ; Verlag: https://doi.org/10.1038/s41467-022-32324-x |
|---|
| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-022-32324-x |
|---|
| | DOI: https://doi.org/10.1038/s41467-022-32324-x |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Cytotoxic T cells |
|---|
| | Immunological memory |
|---|
| | RNA vaccines |
|---|
| | SARS-CoV-2 |
|---|
| K10plus-PPN: | 1822176026 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation / Reinscheid, Matthias [VerfasserIn]; 08 August 2022 (Online-Ressource)
