Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation

• Verfasst von: Wiskemann, Joachim [VerfasserIn]
• Verfasst von: Dreger, Peter [VerfasserIn]
• Verfasst von: Schwerdtfeger, Rainer [VerfasserIn]
• Verfasst von: Bondong, Andrea [VerfasserIn]
• Verfasst von: Huber, Gerhard [VerfasserIn]
• Verfasst von: Kleindienst, Nikolaus [VerfasserIn]
• Verfasst von: Ulrich, Cornelia [VerfasserIn]
• Verfasst von: Bohus, Martin [VerfasserIn]
• Titel: Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation
• Verf.angabe: Joachim Wiskemann, Peter Dreger, Rainer Schwerdtfeger, Andrea Bondong, Gerhard Huber, Nikolaus Kleindienst, Cornelia M. Ulrich, and Martin Bohus
• Jahr: 2011
• Umfang: 10 S.
• Fussnoten: Prepublished online as Blood first edition paper, December 29, 2010 ; Gesehen am 14.11.2022
• Titel Quelle: Enthalten in: Blood
• Ort Quelle: Washington, DC : American Society of Hematology, 1946
• Jahr Quelle: 2011
• Band/Heft Quelle: 117(2011), 9, Seite 2604-2613
• ISSN Quelle: 1528-0020
• DOI: doi:10.1182/blood-2010-09-306308
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1822203139

Abstract

Before, during, and after allogeneic hematopoietic stem cell transplantation (allo-HSCT), patients experience considerable physical and psychologic distress. Besides graft-versus-host disease and infections, reduced physical performance and high levels of fatigue affect patients' quality of life. This multicenter randomized controlled trial examined the effects of a partly self-administered exercise intervention before, during, and after allo-HSCT on these side effects. After randomization to an exercise and a social contact control group 105 patients trained in a home-based setting before hospital admission, during inpatient treatment and a 6- to 8-week period after discharge. Fatigue, physical performance, quality of life, and physical/psychologic distress were measured by standardized instruments at baseline, admission to, and discharge from hospital and 6 to 8 weeks after discharge. The exercise group showed significantly improvement in fatigue scores (up to 15% improvement in exercise group vs up to 28% deterioration in control; P < .01-.03), physical fitness/functioning (P = .02-.03) and global distress (P = .03). All effects were at least detectable at one assessment time point after hospitalization or repeatedly. Physical fitness correlated significantly with all reported symptoms/variables. In conclusion, this partly supervised exercise intervention is beneficial for patients undergoing allo-HSCT. Because of low personnel requirements, it might be valuable to integrate such a program into standard medical care.