Assessment of a serum microrna risk score for colorectal cancer among participants of screening colonoscopy at various stages of colorectal carcinogenesis

• Verfasst von: Raut, Janhavi R. [VerfasserIn]
• Verfasst von: Bhardwaj, Megha [VerfasserIn]
• Verfasst von: Niedermaier, Tobias [VerfasserIn]
• Verfasst von: Miah, Kaya [VerfasserIn]
• Verfasst von: Schrotz-King, Petra [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Titel: Assessment of a serum microrna risk score for colorectal cancer among participants of screening colonoscopy at various stages of colorectal carcinogenesis
• Verf.angabe: Janhavi R. Raut, Megha Bhardwaj, Tobias Niedermaier, Kaya Miah, Petra Schrotz-King and Hermann Brenner
• E-Jahr: 2022
• Jahr: 8 August 2022
• Umfang: 10 S.
• Fussnoten: Gesehen am 14.11.2022
• Titel Quelle: Enthalten in: Cells
• Ort Quelle: Basel : MDPI, 2012
• Jahr Quelle: 2022
• Band/Heft Quelle: 11(2022), 15, Artikel-ID 2462, Seite 1-10
• ISSN Quelle: 2073-4409
• DOI: doi:10.3390/cells11152462
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: blood-based
• Sach-SW: colorectal cancer
• Sach-SW: miRNA
• Sach-SW: risk stratification
• Sach-SW: risk-adapted screening
• K10plus-PPN: 1822349052

Abstract

We recently derived and validated a serum-based microRNA risk score (miR-score) which predicted colorectal cancer (CRC) occurrence with very high accuracy within 14 years of follow-up in a large population-based cohort. Here, we aimed to assess and compare the distribution of the miR-score among participants of screening colonoscopy at various stages of colorectal carcinogenesis. MicroRNAs (miRNAs) were profiled by quantitative-real-time-polymerase-chain-reaction in the serum samples of screening colonoscopy participants with CRC (n = 52), advanced colorectal adenoma (AA, n = 100), non-advanced colorectal adenoma (NAA, n = 88), and participants free of colorectal neoplasms (n = 173). The mean values of the miR-score were compared between groups by the Mann-Whitney U test. The associations of the miR-score with risk for colorectal neoplasms were evaluated using logistic regression analyses. MicroRNA risk scores were significantly higher among participants with AA than among those with NAA (p = 0.027) and those with CRC (p = 0.014), whereas no statistically significant difference was seen between those with NAA and those with no colorectal neoplasms (p = 0.127). When comparing adjacent groups, miR-scores were inversely associated with CRC versus AA and positively associated with AA versus NAA [odds ratio (OR), 0.37 (95% confidence interval (CI), 0.16-0.86) and OR, 2.22 (95% CI, 1.06-4.64) for the top versus bottom tertiles, respectively]. Our results are consistent with the hypothesis that a high miR-score may be indicative of an increased CRC risk by an increased tendency of progression from non-advanced to advanced colorectal neoplasms, along with a change of the miR-patterns after CRC manifestation.