| |  Online-Ressource |
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| Verfasst von: | Abraham, Nixon M. [VerfasserIn]  |
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| | Egger, Veronica [VerfasserIn] |
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| | Shimshek, Derya R. [VerfasserIn] |
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| | Renden, Robert [VerfasserIn] |
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| | Fukunaga, Izumi [VerfasserIn] |
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| | Sprengel, Rolf [VerfasserIn] |
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| | Seeburg, Peter H. [VerfasserIn] |
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| | Klugmann, Matthias [VerfasserIn] |
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| | Margrie, Troy W. [VerfasserIn] |
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| | Schaefer, Andreas T. [VerfasserIn] |
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| | Kuner, Thomas [VerfasserIn] |
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| Titel: | Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice |
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| Verf.angabe: | Nixon M. Abraham, Veronica Egger, Derya R. Shimshek, Robert Renden, Izumi Fukunaga, Rolf Sprengel, Peter H. Seeburg, Matthias Klugmann, Troy W. Margrie, Andreas T. Schaefer, and Thomas Kuner |
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| E-Jahr: | 2010 |
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| Jahr: | 10 February 2010 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 15.11.2022 |
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| Titel Quelle: | Enthalten in: Neuron |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1988 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 65(2010), 3, Seite 399-411 |
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| ISSN Quelle: | 1097-4199 |
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| Abstract: | Local inhibitory circuits are thought to shape neuronal information processing in the central nervous system, but it remains unclear how specific properties of inhibitory neuronal interactions translate into behavioral performance. In the olfactory bulb, inhibition of mitral/tufted cells via granule cells may contribute to odor discrimination behavior by refining neuronal representations of odors. Here we show that selective deletion of the AMPA receptor subunit GluA2 in granule cells boosted synaptic Ca2+ influx, increasing inhibition of mitral cells. On a behavioral level, discrimination of similar odor mixtures was accelerated while leaving learning and memory unaffected. In contrast, selective removal of NMDA receptors in granule cells slowed discrimination of similar odors. Our results demonstrate that inhibition of mitral cells controlled by granule cell glutamate receptors results in fast and accurate discrimination of similar odors. Thus, spatiotemporally defined molecular perturbations of olfactory bulb granule cells directly link stimulus similarity, neuronal processing time, and discrimination behavior to synaptic inhibition. |
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| DOI: | doi:10.1016/j.neuron.2010.01.009 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.neuron.2010.01.009 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0896627310000140 |
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| | DOI: https://doi.org/10.1016/j.neuron.2010.01.009 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | MOLNEURO |
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| | SYSNEURO |
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| K10plus-PPN: | 1822510120 |
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| Verknüpfungen: | → Zeitschrift |
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Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice / Abraham, Nixon M. [VerfasserIn]; 10 February 2010 (Online-Ressource)
