Circulating insulin-like growth factor-I in pregnancy and maternal risk of breast cancer

• Verfasst von: Toriola, Adetunji T. [VerfasserIn]
• Verfasst von: Lundin, Eva [VerfasserIn]
• Verfasst von: Schöck, Helena [VerfasserIn]
• Verfasst von: Grankvist, Kjell [VerfasserIn]
• Verfasst von: Pukkala, Eero [VerfasserIn]
• Verfasst von: Chen, Tianhui [VerfasserIn]
• Verfasst von: Zeleniuch-Jacquotte, Anne [VerfasserIn]
• Verfasst von: Toniolo, Paolo [VerfasserIn]
• Verfasst von: Lehtinen, Matti [VerfasserIn]
• Verfasst von: Surcel, Helja-Marja [VerfasserIn]
• Verfasst von: Lukanova, Annekatrin [VerfasserIn]
• Titel: Circulating insulin-like growth factor-I in pregnancy and maternal risk of breast cancer
• Verf.angabe: Adetunji T. Toriola, Eva Lundin, Helena Schock, Kjell Grankvist, Eero Pukkala, Tianhui Chen, Anne Zeleniuch-Jacquotte, Paolo Toniolo, Matti Lehtinen, Helja-Marja Surcel, and Annekatrin Lukanova
• E-Jahr: 2011
• Jahr: August 07 2011
• Umfang: 4 S.
• Fussnoten: Gesehen am 16.11.2022
• Titel Quelle: Enthalten in: Cancer epidemiology, biomarkers & prevention
• Ort Quelle: Philadelphia, Pa. : AACR, 1991
• Jahr Quelle: 2011
• Band/Heft Quelle: 20(2011), 8, Seite 1798-1801
• ISSN Quelle: 1538-7755
• DOI: doi:10.1158/1055-9965.EPI-11-0441
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1822642949

Abstract

Background: Elevated serum concentrations of insulin-like growth factor (IGF)-I have been associated with increased risk of developing breast cancer. Previously, we reported a similar association in samples obtained during pregnancy. This study was conducted to further characterize the association of IGF-I during pregnancy with maternal breast cancer risk.Methods: A case-control study was nested within the Finnish Maternity Cohort. The study was limited to primiparous women younger than 40 years, who donated blood samples during early (median, 12 weeks) pregnancy and delivered a single child at term. Seven hundred nineteen women with invasive breast cancer were eligible. Two controls (n = 1,434) were matched with each case on age and date at blood donation. Serum IGF-I concentration was measured using an Immulite 2000 analyzer. Conditional logistic regression was used to estimate ORs and 95% CIs.Results: No significant associations were observed between serum IGF-I concentrations and breast cancer risk in both the overall analysis (OR, 1.08; 95% CI, 0.80-1.47) and in analyses stratified by histologic subtype, lag time to cancer diagnosis, age at pregnancy, or age at diagnosis.Conclusion: There was no association between IGF-I and maternal breast cancer risk during early pregnancy in this large nested case-control study.Impact: Serum IGF-I concentrations during early pregnancy may not be related to maternal risk of developing breast cancer. Cancer Epidemiol Biomarkers Prev; 20(8); 1798-801. ©2011 AACR.