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Verfasst von:Toriola, Adetunji T. [VerfasserIn]   i
 Lundin, Eva [VerfasserIn]   i
 Schöck, Helena [VerfasserIn]   i
 Grankvist, Kjell [VerfasserIn]   i
 Pukkala, Eero [VerfasserIn]   i
 Chen, Tianhui [VerfasserIn]   i
 Zeleniuch-Jacquotte, Anne [VerfasserIn]   i
 Toniolo, Paolo [VerfasserIn]   i
 Lehtinen, Matti [VerfasserIn]   i
 Surcel, Helja-Marja [VerfasserIn]   i
 Lukanova, Annekatrin [VerfasserIn]   i
Titel:Circulating insulin-like growth factor-I in pregnancy and maternal risk of breast cancer
Verf.angabe:Adetunji T. Toriola, Eva Lundin, Helena Schock, Kjell Grankvist, Eero Pukkala, Tianhui Chen, Anne Zeleniuch-Jacquotte, Paolo Toniolo, Matti Lehtinen, Helja-Marja Surcel, and Annekatrin Lukanova
E-Jahr:2011
Jahr:August 07 2011
Umfang:4 S.
Fussnoten:Gesehen am 16.11.2022
Titel Quelle:Enthalten in: Cancer epidemiology, biomarkers & prevention
Ort Quelle:Philadelphia, Pa. : AACR, 1991
Jahr Quelle:2011
Band/Heft Quelle:20(2011), 8, Seite 1798-1801
ISSN Quelle:1538-7755
Abstract:Background: Elevated serum concentrations of insulin-like growth factor (IGF)-I have been associated with increased risk of developing breast cancer. Previously, we reported a similar association in samples obtained during pregnancy. This study was conducted to further characterize the association of IGF-I during pregnancy with maternal breast cancer risk.Methods: A case-control study was nested within the Finnish Maternity Cohort. The study was limited to primiparous women younger than 40 years, who donated blood samples during early (median, 12 weeks) pregnancy and delivered a single child at term. Seven hundred nineteen women with invasive breast cancer were eligible. Two controls (n = 1,434) were matched with each case on age and date at blood donation. Serum IGF-I concentration was measured using an Immulite 2000 analyzer. Conditional logistic regression was used to estimate ORs and 95% CIs.Results: No significant associations were observed between serum IGF-I concentrations and breast cancer risk in both the overall analysis (OR, 1.08; 95% CI, 0.80-1.47) and in analyses stratified by histologic subtype, lag time to cancer diagnosis, age at pregnancy, or age at diagnosis.Conclusion: There was no association between IGF-I and maternal breast cancer risk during early pregnancy in this large nested case-control study.Impact: Serum IGF-I concentrations during early pregnancy may not be related to maternal risk of developing breast cancer. Cancer Epidemiol Biomarkers Prev; 20(8); 1798-801. ©2011 AACR.
DOI:doi:10.1158/1055-9965.EPI-11-0441
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1158/1055-9965.EPI-11-0441
 DOI: https://doi.org/10.1158/1055-9965.EPI-11-0441
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1822642949
Verknüpfungen:→ Zeitschrift

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