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Status: Bibliographieeintrag

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Verfasst von:Chen, Di [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
 Nees, Frauke [VerfasserIn]   i
Titel:Brain signatures during reward anticipation predict persistent attention-deficit/hyperactivity disorder symptoms
Verf.angabe:Di Chen, Tianye Jia, Wei Cheng, Miao Cao, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny A. Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, T. W. Robbins, Barbara J. Sahakian, Gunter Schumann, Jianfeng Feng, the IMAGEN Consortium
E-Jahr:2022
Jahr:[August 2022]
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 16.11.2022
Titel Quelle:Enthalten in: American Academy of Child and Adolescent PsychiatryJournal of the American Academy of Child and Adolescent Psychiatry
Ort Quelle:Kidlington [u.a.] : Elsevier, 1987
Jahr Quelle:2022
Band/Heft Quelle:61(2022), 8 vom: Aug., Seite 1050-1061
ISSN Quelle:1527-5418
Abstract:Objective - Children experiencing attention-deficit/hyperactivity disorder (ADHD) symptoms may retain symptoms into adulthood, but little is known about the underlying mechanism. - Method - To identify biomarkers of persistent ADHD symptom development, we carried out whole-brain analyses of neuroimaging data during the anticipation phase of the Monetary-Incentive-Delay (MID) task in 1,368 adolescents recruited by the IMAGEN Consortium at age 14 years, whose behavioral measurements were followed up longitudinally at age 16. In particular, we focused on comparing individuals with persistent high ADHD symptoms at both ages 14 and 16 years to unaffected control individuals, but also exploring which individuals demonstrating symptom remission (with high ADHD symptoms at age 14 but much reduced at age 16). - Results - We identified reduced activations in the medial frontal cortex and the thalamus during reward anticipation as neuro-biomarkers for persistent ADHD symptoms across time. The genetic relevance of the above findings was further supported by the associations of the polygenic risk scores of ADHD with both the persistent and control status and the activations of both brain regions. Furthermore, in an exploratory analysis, the thalamic activation might also help to distinguish persons with persistent ADHD from those remitted in both an exploratory sample (odds ratio = 9.43, p < .001) and an independent generalization sample (odds ratio = 4.64, p = .003). - Conclusion - Using a well-established and widely applied functional magnetic resonance imaging task, we have identified neural biomarkers that could discriminate ADHD symptoms that persist throughout adolescence from controls and potentially those likely to remit during adolescent development as well.
DOI:doi:10.1016/j.jaac.2021.11.030
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.jaac.2021.11.030
 Volltext: https://www.sciencedirect.com/science/article/pii/S0890856721020529
 DOI: https://doi.org/10.1016/j.jaac.2021.11.030
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:attention-deficit/hyperactivity disorder
 functional magnetic resonance imaging
 monetary incentive delay
 polygenic risk score
 Strengths and Difficulties Questionnaire
K10plus-PPN:1822680921
Verknüpfungen:→ Zeitschrift

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