| |  Online-Ressource |
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| Verfasst von: | Li, Jin [VerfasserIn]  |
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| | Liu, Bing [VerfasserIn] |
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| | Banaschewski, Tobias [VerfasserIn] |
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| | Bokde, Arun L. W. [VerfasserIn] |
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| | Quinlan, Erin Burke [VerfasserIn] |
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| | Desrivières, Sylvane [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Frouin, Vincent [VerfasserIn] |
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| | Garavan, Hugh [VerfasserIn] |
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| | Gowland, Penny [VerfasserIn] |
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| | Heinz, Andreas [VerfasserIn] |
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| | Ittermann, Bernd [VerfasserIn] |
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| | Martinot, Jean-Luc [VerfasserIn] |
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| | Artiges, Eric [VerfasserIn] |
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| | Nees, Frauke [VerfasserIn] |
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| | Orfanos, Dimitri Papadopoulos [VerfasserIn] |
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| | Paus, Tomáš [VerfasserIn] |
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| | Poustka, Luise [VerfasserIn] |
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| | Hohmann, Sarah [VerfasserIn] |
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| | Fröhner, Juliane H. [VerfasserIn] |
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| | Smolka, Michael N. [VerfasserIn] |
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| | Walter, Henrik [VerfasserIn] |
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| | Whelan, Robert [VerfasserIn] |
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| | Schumann, Gunter [VerfasserIn] |
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| | Jiang, Tianzi [VerfasserIn] |
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| Titel: | Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents |
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| Verf.angabe: | Jin Li, Bing Liu, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, IMAGEN Consortium, and Tianzi Jiang |
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| E-Jahr: | 2022 |
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| Jahr: | [2022] |
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| Umfang: | 8 S. |
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| Illustrationen: | 1 Illustration |
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| Fussnoten: | Gesehen am 16.11.222 |
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| Titel Quelle: | Enthalten in: Psychological medicine |
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| Ort Quelle: | Cambridge : Cambridge University Press, 1970 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 52(2022), 6, Seite 1175-1182 |
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| ISSN Quelle: | 1469-8978 |
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| Abstract: | BackgroundTobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood.MethodsGenomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use.ResultsA higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use.ConclusionsOur data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure. |
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| DOI: | doi:10.1017/S0033291720002962 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1017/S0033291720002962 |
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| | Volltext: https://www.cambridge.org/core/journals/psychological-medicine/article/orbitofrontal-cortex-volume-links-polygenic-risk- ... |
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| | DOI: https://doi.org/10.1017/S0033291720002962 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cortical volume |
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| | orbitofrontal cortex |
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| | polygenic risk score |
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| | smoking |
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| | tobacco use |
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| K10plus-PPN: | 1822689686 |
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| Verknüpfungen: | → Zeitschrift |
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Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents / Li, Jin [VerfasserIn]; [2022] (Online-Ressource)
