MicroRNA function in the nervous system

• Verfasst von: Fiore, Roberto [VerfasserIn]
• Verfasst von: Khudayberdiev, Sharof Abdumalikovich [VerfasserIn]
• Verfasst von: Saba, Reuben [VerfasserIn]
• Verfasst von: Schratt, Gerhard [VerfasserIn]
• Titel: MicroRNA function in the nervous system
• Verf.angabe: Roberto Fiore, Sharof Khudayberdiev, Reuben Saba, Gerhard Schratt
• E-Jahr: 2011
• Jahr: 16. August 2011
• Umfang: 54 S.
• Fussnoten: Teil des Bandes: Mechanismen der zellulären RNA-Interferenz ; Gesehen am 17.11.2022
• Titel Quelle: Enthalten in: Progress in molecular biology and translational science
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 2008
• Jahr Quelle: 2011
• Band/Heft Quelle: 102(2011), Seite 47-100
• ISSN Quelle: 1878-0814
• DOI: doi:10.1016/B978-0-12-415795-8.00004-0
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: MicroRNA
• Sach-SW: Neurological disease
• Sach-SW: Neuronal activity
• Sach-SW: Neuronal differentiation
• Sach-SW: Synaptic plasticity
• Sach-SW: Synaptogenesis
• K10plus-PPN: 1822824923

Abstract

MicroRNAs (miRNAs) are an extensive class of small noncoding RNAs that control posttranscriptional gene expression. miRNAs are highly expressed in neurons where they play key roles during neuronal differentiation, synaptogenesis, and plasticity. It is also becoming increasingly evident that miRNAs have a profound impact on higher cognitive functions and are involved in the etiology of several neurological diseases and disorders. In this chapter, we summarize our current knowledge of miRNA functions during neuronal development, physiology, and dysfunction.