| |  Online-Ressource |
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| Verfasst von: | Bakker, Barbara M. [VerfasserIn]  |
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| | Krauth-Siegel, Renate [VerfasserIn] |
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| | Clayton, Christine [VerfasserIn] |
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| | Matthews, Keith [VerfasserIn] |
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| | Girolami, Mark [VerfasserIn] |
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| | Westerhoff, Hans V. [VerfasserIn] |
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| | Michels, Paul A. M. [VerfasserIn] |
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| | Breitling, Rainer [VerfasserIn] |
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| | Barrett, Michael P. [VerfasserIn] |
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| Titel: | The silicon trypanosome |
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| Verf.angabe: | Barbara M. Bakker, R. Luise Krauth-Siegel, Christine Clayton, Keith Matthews, Mark Girolami, Hans V. Westerhoff, Paul A. M. Michels, Rainer Breitling and Michael P. Barrett |
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| E-Jahr: | 2010 |
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| Jahr: | 6 May 2010 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 18.11.2022 |
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| Titel Quelle: | Enthalten in: Parasitology |
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| Ort Quelle: | Cambridge [u.a.] : Cambridge Univ. Press, 1908 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 137(2010), 9, Seite 1333-1341 |
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| ISSN Quelle: | 1469-8161 |
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| Abstract: | African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history of quantitative research. Reproducible cultivation methods exist for morphologically and physiologically distinct life-cycle stages. The genome has been sequenced, and microarrays, RNA-interference and high-accuracy metabolomics are available. Furthermore, the availability of extensive kinetic data on all glycolytic enzymes has led to the early development of a complete, experiment-based dynamic model of an important biochemical pathway. Here we describe the achievements of trypanosome systems biology so far and outline the necessary steps towards the ambitious aim of creating a 'Silicon Trypanosome', a comprehensive, experiment-based, multi-scale mathematical model of trypanosome physiology. We expect that, in the long run, the quantitative modelling enabled by the Silicon Trypanosome will play a key role in selecting the most suitable targets for developing new anti-parasite drugs. |
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| DOI: | doi:10.1017/S0031182010000466 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
DOI: https://doi.org/10.1017/S0031182010000466 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Parasitology |
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| | Systems Biology |
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| | Trypanosoma |
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| K10plus-PPN: | 1822982480 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ silicon trypanosome / Bakker, Barbara M. [VerfasserIn]; 6 May 2010 (Online-Ressource)
