Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease

• Verfasst von: Witt, Karsten [VerfasserIn]
• Verfasst von: Daniels, Christine [VerfasserIn]
• Verfasst von: Krack, Paul [VerfasserIn]
• Verfasst von: Volkmann, Jens [VerfasserIn]
• Verfasst von: Pinsker, Markus O. [VerfasserIn]
• Verfasst von: Kloss, Manja [VerfasserIn]
• Verfasst von: Tronnier, Volker [VerfasserIn]
• Verfasst von: Schnitzler, Alfons [VerfasserIn]
• Verfasst von: Wojtecki, Lars [VerfasserIn]
• Verfasst von: Bötzel, Kai [VerfasserIn]
• Verfasst von: Danek, Adrian [VerfasserIn]
• Verfasst von: Hilker, Rüdiger [VerfasserIn]
• Verfasst von: Sturm, Volker [VerfasserIn]
• Verfasst von: Kupsch, Andreas [VerfasserIn]
• Verfasst von: Karner, Elfriede [VerfasserIn]
• Verfasst von: Deuschl, Günther [VerfasserIn]
• Titel: Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson's disease
• Verf.angabe: Karsten Witt, Christine Daniels, Paul Krack, Jens Volkmann, Markus O. Pinsker, Manja Kloss, Volker Tronnier, Alfons Schnitzler, Lars Wojtecki, Kai Bötzel, Adrian Danek, Rüdiger Hilker, Volker Sturm, Andreas Kupsch, Elfriede Karner, Günther Deuschl
• E-Jahr: 2011
• Jahr: 5 July 2011
• Umfang: 6 S.
• Fussnoten: Gesehen am 21.11.2022
• Titel Quelle: Enthalten in: Journal of the neurological sciences
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1964
• Jahr Quelle: 2011
• Band/Heft Quelle: 310(2011), 1/2, Seite 261-266
• ISSN Quelle: 1878-5883
• DOI: doi:10.1016/j.jns.2011.06.028
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cognition
• Sach-SW: Deep brain stimulation
• Sach-SW: Nucleus subthalamicus
• Sach-SW: Parkinson's disease
• Sach-SW: Quality of life
• K10plus-PPN: 1823004164

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in Parkinson's disease (PD). Dementia is considered as a contraindication for STN-DBS. However, no controlled study assessed the impact of STN-DBS on the QoL and motor outcome in PD patients with a borderline global cognitive impairment. We studied clinical baseline and progression parameters in a cohort of STN-DBS patients with a global cognitive score still in the non-demented range but scoring in the lowest quartile of the Mattis Dementia Rating Scale (MDRS), a measure of global cognitive functioning. Data from a German randomised controlled study comparing DBS (60 patients) with best medical treatment (BMT, 59 patients) were analysed. Changes in patients' QoL scores were assessed using the Parkinson's disease questionnaire (PDQ-39) at baseline and at the 6months follow up. Patients were split into four groups according to their MDRS performance at baseline and these groups were compared in the context of motor outcome and QoL. Twelve out of sixty patients of the STN-DBS group scored in the lowest quartile of the MDRS (range between one hundred thirty and one hundred thirty seven points). An individual analysis revealed that 3 of 12 patients showed a clinical relevant improvement in QoL whereas the group statistics did not reveal any significant improvement in QoL measures after STN-DBS compared to the BMT group. Since this failure to improve in QoL cannot be explained by a failure to improve in motor functions, stimulation settings and psychiatric scales after STN-DBS, the failure to improve in QoL in patients with a borderline global cognitive score might be specifically related to lower cognitive functioning.