Does there exist an obesity paradox in COVID-19?

• Verfasst von: Abumayyaleh, Mohammad S. A. [VerfasserIn]
• Verfasst von: Núñez Gil, Iván J. [VerfasserIn]
• Verfasst von: El-Battrawy, Ibrahim [VerfasserIn]
• Verfasst von: Estrada, Vicente [VerfasserIn]
• Verfasst von: Becerra-Muñoz, Víctor Manuel [VerfasserIn]
• Verfasst von: Aparisi, Alvaro [VerfasserIn]
• Verfasst von: Fernández-Rozas, Inmaculada [VerfasserIn]
• Verfasst von: Feltes, Gisela [VerfasserIn]
• Verfasst von: Arroyo-Espliguero, Ramón [VerfasserIn]
• Verfasst von: Trabattoni, Daniela [VerfasserIn]
• Verfasst von: López-País, Javier [VerfasserIn]
• Verfasst von: Pepe, Martino [VerfasserIn]
• Verfasst von: Romero, Rodolfo [VerfasserIn]
• Verfasst von: García, Diego Raúl Villavicencio [VerfasserIn]
• Verfasst von: Biole, Carloalberto [VerfasserIn]
• Verfasst von: Astrua, Thamar Capel [VerfasserIn]
• Verfasst von: Eid, Charbel Maroun [VerfasserIn]
• Verfasst von: Alfonso, Emilio [VerfasserIn]
• Verfasst von: Fernandez-Presa, Lucia [VerfasserIn]
• Verfasst von: Espejo, Carolina [VerfasserIn]
• Verfasst von: Buonsenso, Danilo [VerfasserIn]
• Verfasst von: Raposeiras, Sergio [VerfasserIn]
• Verfasst von: Fernández, Cristina [VerfasserIn]
• Verfasst von: Macaya, Carlos [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Titel: Does there exist an obesity paradox in COVID-19?
• Titelzusatz: insights of the international HOPE-COVID-19-registry
• Verf.angabe: Mohammad Abumayyaleh, Iván J. Núñez Gil, Ibrahim El-Battrawy, Vicente Estrada, Víctor Manuel Becerra-Muñoz, Alvaro Aparisi, Inmaculada Fernández-Rozas, Gisela Feltes, Ramón Arroyo-Espliguero, Daniela Trabattoni, Javier López-País, Martino Pepe, Rodolfo Romero, Diego Raúl Villavicencio García, Carloalberto Biole, Thamar Capel Astrua, Charbel Maroun Eid, Emilio Alfonso, Lucia Fernandez-Presa, Carolina Espejo, Danilo Buonsenso, Sergio Raposeiras, Cristina Fernández, Carlos Macaya, Ibrahim Akin
• E-Jahr: 2021
• Jahr: May-June 2021
• Umfang: 6 S.
• Fussnoten: Gesehen am 23.11.2022
• Titel Quelle: Enthalten in: Obesity research & clinical practice
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 2007
• Jahr Quelle: 2021
• Band/Heft Quelle: 15(2021), 3 vom: Mai/Juni, Seite 275-280
• ISSN Quelle: 1878-0318
• DOI: doi:10.1016/j.orcp.2021.02.008
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: BMI
• Sach-SW: COVID-19
• Sach-SW: Obesity paradox
• Sach-SW: SARS-CoV-2
• K10plus-PPN: 1823265553

Abstract

Background - Obesity has been described as a protective factor in cardiovascular and other diseases being expressed as ‘obesity paradox’. However, the impact of obesity on clinical outcomes including mortality in COVID-19 has been poorly systematically investigated until now. We aimed to compare clinical outcomes among COVID-19 patients divided into three groups according to the body mass index (BMI). - Methods - We retrospectively collected data up to May 31st, 2020. 3635 patients were divided into three groups of BMI (<25 kg/m2; n = 1110, 25−30 kg/m2; n = 1464, and >30 kg/m2; n = 1061). Demographic, in-hospital complications, and predictors for mortality, respiratory insufficiency, and sepsis were analyzed. - Results - The rate of respiratory insufficiency was more recorded in BMI 25−30 kg/m2 as compared to BMI < 25 kg/m2 (22.8% vs. 41.8%; p < 0.001), and in BMI > 30 kg/m2 than BMI < 25 kg/m2, respectively (22.8% vs. 35.4%; p < 0.001). Sepsis was more observed in BMI 25−30 kg/m2 and BMI > 30 kg/m2 as compared to BMI < 25 kg/m2, respectively (25.1% vs. 42.5%; p = 0.02) and (25.1% vs. 32.5%; p = 0.006). The mortality rate was higher in BMI 25−30 kg/m2 and BMI > 30 kg/m2 as compared to BMI < 25 kg/m2, respectively (27.2% vs. 39.2%; p = 0.31) (27.2% vs. 33.5%; p = 0.004). In the Cox multivariate analysis for mortality, BMI < 25 kg/m2 and BMI > 30 kg/m2 did not impact the mortality rate (HR 1.15, 95% CI: 0.889−1.508; p = 0.27) (HR 1.15, 95% CI: 0.893−1.479; p = 0.27). In multivariate logistic regression analyses for respiratory insufficiency and sepsis, BMI < 25 kg/m2 is determined as an independent predictor for reduction of respiratory insufficiency (OR 0.73, 95% CI: 0.538−1.004; p = 0.05). - Conclusions - HOPE COVID-19-Registry revealed no evidence of obesity paradox in patients with COVID-19. However, Obesity was associated with a higher rate of respiratory insufficiency and sepsis but was not determined as an independent predictor for a high mortality.