Difficulties of interpreting Borrelia Serology in patients with Uveitis

• Verfasst von: Mackensen, Friederike [VerfasserIn]
• Verfasst von: Zimmermann, Stefan [VerfasserIn]
• Verfasst von: Alle, Werner [VerfasserIn]
• Verfasst von: Max, Regina [VerfasserIn]
• Verfasst von: Jakob, Eva [VerfasserIn]
• Verfasst von: Becker, Matthias D. [VerfasserIn]
• Verfasst von: Thiemeyer, Dorothea [VerfasserIn]
• Titel: Difficulties of interpreting Borrelia Serology in patients with Uveitis
• Verf.angabe: Friederike Mackensen, Stefan Zimmermann, Werner Alle, Regina Max, Eva Jakob, Matthias D. Becker and Dorothea Thiemeyer
• Jahr: 2011
• Umfang: 5 S.
• Fussnoten: Gesehen am 24.11.2022
• Titel Quelle: Enthalten in: Ocular immunology and inflammation
• Ort Quelle: Abingdon : Taylor & Francis Group, 1993
• Jahr Quelle: 2011
• Band/Heft Quelle: 19(2011), 4, Seite 227-231
• ISSN Quelle: 1744-5078
• DOI: doi:10.3109/09273948.2011.568662
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Bayes Theorem
• Sach-SW: Borrelia serology
• Sach-SW: Interferon gamma release assay
• Sach-SW: usefulness of serological test
• Sach-SW: uveitis and Borrelia
• K10plus-PPN: 1823554733

Abstract

Purpose: We aimed to review all uveitis patients with a positive Borrelia serology to evaluate positve results in uveitis subtypes. Further we wanted to test a self-assembled Interferon gamma release assay (IGRA) as a possible supplement method in these patients.Methods: Patients where serology for Borrelia was ordered from September 2005 to May 2008, were identified by database search. Patients with positive results in ELISA and Western Blot were retested by a self-assembled IGRA. Bayes Theorem was applied.Results: Testing for Borrelia was ordered for 184 patients. 18 patients (9,8%) showed positive results. 11 were positive for IgG (5,9 %), 3 were positive for IgG and IgM (1,6 %) and 4 for IgM (2,1%). Applying Bayes Theorem, we calculated a posttest-probability of 9% in case of a positive test result. 16 of the 18 patients were retested by IGRA. None of them showed a positive result.Conclusions: A positive serology with uveitis as the only clinical symptom is not sufficient to confirm Borreliosis as 5,9 % of patients with uveitis and a positive IgG serology correspond to the normal spread of Borrelia in the population. Looking at posttest-probability shows a lot of false-positive test results when testing all uveitis patients for Borrelia routinely.