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Verfasst von:Mackensen, Friederike [VerfasserIn]   i
 Zimmermann, Stefan [VerfasserIn]   i
 Alle, Werner [VerfasserIn]   i
 Max, Regina [VerfasserIn]   i
 Jakob, Eva [VerfasserIn]   i
 Becker, Matthias D. [VerfasserIn]   i
 Thiemeyer, Dorothea [VerfasserIn]   i
Titel:Difficulties of interpreting Borrelia Serology in patients with Uveitis
Verf.angabe:Friederike Mackensen, Stefan Zimmermann, Werner Alle, Regina Max, Eva Jakob, Matthias D. Becker and Dorothea Thiemeyer
Jahr:2011
Umfang:5 S.
Fussnoten:Gesehen am 24.11.2022
Titel Quelle:Enthalten in: Ocular immunology and inflammation
Ort Quelle:Abingdon : Taylor & Francis Group, 1993
Jahr Quelle:2011
Band/Heft Quelle:19(2011), 4, Seite 227-231
ISSN Quelle:1744-5078
Abstract:Purpose: We aimed to review all uveitis patients with a positive Borrelia serology to evaluate positve results in uveitis subtypes. Further we wanted to test a self-assembled Interferon gamma release assay (IGRA) as a possible supplement method in these patients.Methods: Patients where serology for Borrelia was ordered from September 2005 to May 2008, were identified by database search. Patients with positive results in ELISA and Western Blot were retested by a self-assembled IGRA. Bayes Theorem was applied.Results: Testing for Borrelia was ordered for 184 patients. 18 patients (9,8%) showed positive results. 11 were positive for IgG (5,9 %), 3 were positive for IgG and IgM (1,6 %) and 4 for IgM (2,1%). Applying Bayes Theorem, we calculated a posttest-probability of 9% in case of a positive test result. 16 of the 18 patients were retested by IGRA. None of them showed a positive result.Conclusions: A positive serology with uveitis as the only clinical symptom is not sufficient to confirm Borreliosis as 5,9 % of patients with uveitis and a positive IgG serology correspond to the normal spread of Borrelia in the population. Looking at posttest-probability shows a lot of false-positive test results when testing all uveitis patients for Borrelia routinely.
DOI:doi:10.3109/09273948.2011.568662
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3109/09273948.2011.568662
 Volltext: https://www.tandfonline.com/doi/full/10.3109/09273948.2011.568662
 DOI: https://doi.org/10.3109/09273948.2011.568662
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Bayes Theorem
 Borrelia serology
 Interferon gamma release assay
 usefulness of serological test
 uveitis and Borrelia
K10plus-PPN:1823554733
Verknüpfungen:→ Zeitschrift

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