| Online-Ressource |
Verfasst von: | Mackensen, Friederike [VerfasserIn]  |
| Zimmermann, Stefan [VerfasserIn]  |
| Alle, Werner [VerfasserIn]  |
| Max, Regina [VerfasserIn]  |
| Jakob, Eva [VerfasserIn]  |
| Becker, Matthias D. [VerfasserIn]  |
| Thiemeyer, Dorothea [VerfasserIn]  |
Titel: | Difficulties of interpreting Borrelia Serology in patients with Uveitis |
Verf.angabe: | Friederike Mackensen, Stefan Zimmermann, Werner Alle, Regina Max, Eva Jakob, Matthias D. Becker and Dorothea Thiemeyer |
Jahr: | 2011 |
Umfang: | 5 S. |
Fussnoten: | Gesehen am 24.11.2022 |
Titel Quelle: | Enthalten in: Ocular immunology and inflammation |
Ort Quelle: | Abingdon : Taylor & Francis Group, 1993 |
Jahr Quelle: | 2011 |
Band/Heft Quelle: | 19(2011), 4, Seite 227-231 |
ISSN Quelle: | 1744-5078 |
Abstract: | Purpose: We aimed to review all uveitis patients with a positive Borrelia serology to evaluate positve results in uveitis subtypes. Further we wanted to test a self-assembled Interferon gamma release assay (IGRA) as a possible supplement method in these patients.Methods: Patients where serology for Borrelia was ordered from September 2005 to May 2008, were identified by database search. Patients with positive results in ELISA and Western Blot were retested by a self-assembled IGRA. Bayes Theorem was applied.Results: Testing for Borrelia was ordered for 184 patients. 18 patients (9,8%) showed positive results. 11 were positive for IgG (5,9 %), 3 were positive for IgG and IgM (1,6 %) and 4 for IgM (2,1%). Applying Bayes Theorem, we calculated a posttest-probability of 9% in case of a positive test result. 16 of the 18 patients were retested by IGRA. None of them showed a positive result.Conclusions: A positive serology with uveitis as the only clinical symptom is not sufficient to confirm Borreliosis as 5,9 % of patients with uveitis and a positive IgG serology correspond to the normal spread of Borrelia in the population. Looking at posttest-probability shows a lot of false-positive test results when testing all uveitis patients for Borrelia routinely. |
DOI: | doi:10.3109/09273948.2011.568662 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3109/09273948.2011.568662 |
| Volltext: https://www.tandfonline.com/doi/full/10.3109/09273948.2011.568662 |
| DOI: https://doi.org/10.3109/09273948.2011.568662 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Bayes Theorem |
| Borrelia serology |
| Interferon gamma release assay |
| usefulness of serological test |
| uveitis and Borrelia |
K10plus-PPN: | 1823554733 |
Verknüpfungen: | → Zeitschrift |
Difficulties of interpreting Borrelia Serology in patients with Uveitis / Mackensen, Friederike [VerfasserIn]; 2011 (Online-Ressource)