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Status: Bibliographieeintrag

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Verfasst von:MacPherson, Jamie I. [VerfasserIn]   i
 Sidders, Ben [VerfasserIn]   i
 Wieland, Stefan [VerfasserIn]   i
 Zhong, Jin [VerfasserIn]   i
 Targett-Adams, Paul [VerfasserIn]   i
 Lohmann, Volker [VerfasserIn]   i
 Backes, Perdita [VerfasserIn]   i
 Delpuech-Adams, Oona [VerfasserIn]   i
 Chisari, Francis [VerfasserIn]   i
 Lewis, Marilyn [VerfasserIn]   i
 Parkinson, Tanya [VerfasserIn]   i
 Robertson, David L. [VerfasserIn]   i
Titel:An integrated transcriptomic and meta-analysis of hepatoma cells reveals factors that influence susceptibility to HCV infection
Verf.angabe:Jamie I. MacPherson, Ben Sidders, Stefan Wieland, Jin Zhong, Paul Targett-Adams, Volker Lohmann, Perdita Backes, Oona Delpuech-Adams, Francis Chisari, Marilyn Lewis, Tanya Parkinson, David L. Robertson
E-Jahr:2011
Jahr:October 2011
Umfang:18 S.
Fussnoten:Gesehen am 25.11.2022
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2011
Band/Heft Quelle:6(2011), 10 vom: Okt., Artikel-ID e25584, Seite 1-18
ISSN Quelle:1932-6203
Abstract:Hepatitis C virus (HCV) is a global problem. To better understand HCV infection researchers employ in vitro HCV cell-culture (HCVcc) systems that use Huh-7 derived hepatoma cells that are particularly permissive to HCV infection. A variety of hyper-permissive cells have been subcloned for this purpose. In addition, subclones of Huh-7 which have evolved resistance to HCV are available. However, the mechanisms of susceptibility or resistance to infection among these cells have not been fully determined. In order to elucidate mechanisms by which hepatoma cells are susceptible or resistant to HCV infection we performed genome-wide expression analyses of six Huh-7 derived cell cultures that have different levels of permissiveness to infection. A great number of genes, representing a wide spectrum of functions are differentially expressed between cells. To focus our investigation, we identify host proteins from HCV replicase complexes, perform gene expression analysis of three HCV infected cells and conduct a detailed analysis of differentially expressed host factors by integrating a variety of data sources. Our results demonstrate that changes relating to susceptibility to HCV infection in hepatoma cells are linked to the innate immune response, secreted signal peptides and host factors that have a role in virus entry and replication. This work identifies both known and novel host factors that may influence HCV infection. Our findings build upon current knowledge of the complex interplay between HCV and the host cell, which could aid development of new antiviral strategies.
DOI:doi:10.1371/journal.pone.0025584
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0025584
 kostenfrei: Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025584
 DOI: https://doi.org/10.1371/journal.pone.0025584
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Gene expression
 Gene regulation
 Hepatitis C virus
 Hepatoma cells
 Microarrays
 Subcloning
 Viral gene expression
 Virus effects on host gene expression
K10plus-PPN:1823590365
Verknüpfungen:→ Zeitschrift

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