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Verfasst von:Schlegel, Philipp [VerfasserIn]   i
 Crespo López, Patricia [VerfasserIn]   i
 Kreußer, Michael [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
 Frey, Norbert [VerfasserIn]   i
 Geis, Nicolas [VerfasserIn]   i
 Raake, Philip [VerfasserIn]   i
Titel:PASCAL-based mitral valve repair in an all-comer population
Titelzusatz:acute and mid-term clinical results
Verf.angabe:Philipp Schlegel, Patricia Crespo López, Michael M. Kreusser, Hugo A. Katus, Norbert Frey, Nicolas A. Geis and Philip W.J. Raake
E-Jahr:2021
Jahr:27 August 2021
Umfang:9 S.
Fussnoten:Gesehen am 28.11.2022
Titel Quelle:Enthalten in: European Society of CardiologyESC heart failure
Ort Quelle:Chichester : Wiley, 2014
Jahr Quelle:2021
Band/Heft Quelle:8(2021), 5, Seite 3530-3538
ISSN Quelle:2055-5822
Abstract:Aims We investigated short and mid-term safety and efficacy of the PASCAL system for percutaneous mitral valve repair (PMVr) in severe mitral regurgitation (MR) in an all-comer population. Methods and results In the first consecutive 41 patients undergoing PMVr using the PASCAL system in our centre, procedural success and safety were assessed. Efficacy in improving MR and functional class were evaluated. Median patient age was 74 years, 58.5% were male patients, and median European System for Cardiac Operative Risk Evaluation Score II was 5.1%. All patients suffered from severe MR with 59% functional MR, 29% degenerative MR, and 12% of mixed aetiology MR. The technical success rate was 90%, limited by four cases where PASCAL implantation was aborted due to a prohibitive mitral gradient. On average, 1.16 PASCAL devices per patient were implanted. All patients successfully implanted with a PASCAL device were discharged with MR grade ≤ 2 and 79% with MR grade ≤ 1. Mean follow-up was 8.7 ± 4.9 months. Ninety-seven per cent of patients remained at MR ≤ 2 at follow-up, which translated into a significantly improved New York Heart Association functional class as well as a significant reduction of systolic pulmonary artery pressure and brain natriuretic peptide levels. The procedure-related rate for major adverse events was 3%. Neither early nor late single-leaflet detachment was found. In one patient, air embolism occurred, resulting in modification of the PASCAL instructions for use. Conclusions Percutaneous mitral valve repair using PASCAL in a real-world, all-comer population was feasible and safe, resulting in a significant mid-term reduction of MR with persistent clinical improvement.
DOI:doi:10.1002/ehf2.13569
URL:kostenfrei: Volltext ; Verlag: https://doi.org/10.1002/ehf2.13569
 kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.13569
 DOI: https://doi.org/10.1002/ehf2.13569
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Edge-to-edge repair
 Heart failure
 Leaflet repair
 Mitral valve regurgitation
 Mitral valve repair
 PASCAL device
K10plus-PPN:1823784720
Verknüpfungen:→ Zeitschrift
 
 
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