| |  Online-Ressource |
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| Verfasst von: | Peterziel, Heike [VerfasserIn]  |
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| | Sackmann, T. [VerfasserIn] |
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| | Strelau, Jens [VerfasserIn] |
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| | Kuhn, P. H. [VerfasserIn] |
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| | Lichtenthaler, S. F. [VerfasserIn] |
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| | Marom, K. [VerfasserIn] |
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| | Klar, A. [VerfasserIn] |
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| | Unsicker, Klaus [VerfasserIn] |
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| Titel: | F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion |
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| Verf.angabe: | H. Peterziel, T. Sackmann, J. Strelau, P.H. Kuhn, S.F. Lichtenthaler, K. Marom, A. Klar, K. Unsicker |
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| Jahr: | 2011 |
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| Umfang: | 15 S. |
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| Fussnoten: | Available online: 9 December 2010 ; Gesehen am 29.11.2022 |
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| Titel Quelle: | Enthalten in: Molecular and cellular neuroscience |
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| Ort Quelle: | San Diego, Calif. : Elsevier, 1990 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 46(2011), 2, Seite 483-497 |
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| ISSN Quelle: | 1095-9327 |
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| Abstract: | The extracellular membrane-associated protein F-spondin has been implicated in cell-matrix and cell-cell adhesion and plays an important role in axonal pathfinding. We report here that F-spondin is expressed in non-neuronal cells in the embryonic chicken ciliary ganglion (CG) and robustly promotes survival of cultured CG neurons. Using deletion constructs of F-spondin we found that the amino-terminal Reelin/Spondin domain cooperates with thrombospondin type 1 repeat (TSR) 6, a functional TGFβ-activation domain. In ovo treatment with blocking antibodies raised against the Reelin/Spondin domain or the TSR-domains caused increased apoptosis of CG neurons during the phase of programmed cell death and loss of about 30% of the neurons compared to controls. The Reelin/Spondin domain receptor - APP and its downstream signalling molecule disabled-1 are expressed in CG neurons. F-spondin induced rapid phosphorylation of disabled-1. Moreover, both blocking the central APP domain and interference with disabled-1 signalling disrupted the survival promoting effect of F-spondin. Taken together, our data suggest that F-spondin can promote neuron survival by a mechanism involving the Reelin/Spondin and the TSR domains. |
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| DOI: | doi:10.1016/j.mcn.2010.12.001 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.mcn.2010.12.001 |
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| | DOI: https://doi.org/10.1016/j.mcn.2010.12.001 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adaptor Proteins, Signal Transducing |
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| | Animals |
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| | Apoptosis |
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| | Cell Survival |
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| | Chick Embryo |
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| | Extracellular Matrix Proteins |
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| | Ganglia, Parasympathetic |
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| | Humans |
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| | Immunoblotting |
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| | Immunohistochemistry |
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| | In Situ Hybridization |
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| | In Situ Nick-End Labeling |
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| | Nerve Tissue Proteins |
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| | Neurogenesis |
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| | Neurons |
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| | Reelin Protein |
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| | Transfection |
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| K10plus-PPN: | 1823844669 |
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| Verknüpfungen: | → Zeitschrift |
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F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion / Peterziel, Heike [VerfasserIn]; 2011 (Online-Ressource)
