Chemical composition and antiproliferative activity of essential oil from the leaves of a medicinal herb, Levisticum officinale, against UMSCC1 head and neck squamous carcinoma cells

• Verfasst von: Sertel, Serkan [VerfasserIn]
• Verfasst von: Eichhorn, Tolga [VerfasserIn]
• Verfasst von: Plinkert, Peter K. [VerfasserIn]
• Verfasst von: Efferth, Thomas [VerfasserIn]
• Titel: Chemical composition and antiproliferative activity of essential oil from the leaves of a medicinal herb, Levisticum officinale, against UMSCC1 head and neck squamous carcinoma cells
• Verf.angabe: Serkan Sertel, Tolga Eichhorn, Peter K. Plinkert and Thomas Efferth
• E-Jahr: 2011
• Jahr: [January 2011]
• Umfang: 7 S.
• Illustrationen: Diagramme
• Fussnoten: Gesehen am 30.11.2022
• Titel Quelle: Enthalten in: Anticancer research
• Ort Quelle: Attiki, 2004
• Jahr Quelle: 2011
• Band/Heft Quelle: 31(2011), 1 vom: Jan., Seite 185-191
• ISSN Quelle: 1791-7530
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: head and neck squamous cell carcinoma HNSCC
• Sach-SW: Levisticum officinale lovage
• Sach-SW: natural product
• Sach-SW: oral cavity squamous cell carcinoma OCSCC
• Sach-SW: pharmacogenomics
• K10plus-PPN: 1823952488

Abstract

Background: Oral squamous cell carcinoma (OSCC) is a challenging disease with a high mortality rate. Natural products represent a valuable source for the development of novel anticancer drugs. We investigated the cytotoxic potential of essential oil from the leaves of a medicinal plant, Levisticum officinale (lovage) on head and neck squamous carcinoma cells (HNSCC). Materials and Methods: Cytotoxicity of lovage essential oil was investigated on the HNSCC cell line, UMSCC1. Additionally, we performed pharmacogenomics analyses. Results: Lovage essential oil extract had an IC50 value of 292.6 μg/ml. Genes involved in apoptosis, cancer, cellular growth and cell cycle regulation were the most prominently affected in microarray analyses. The three pathways to be most significantly regulated were extracellular signal-regulated kinase 5 (ERK5) signaling, integrin-linked kinase (ILK) signaling, virus entry via endocytic pathways and p53 signaling. Conclusion: Levisticum officinale essential oil inhibits human HNSCC cell growth.