The evolving plasticity of coagulation protease-dependent cytoprotective signalling

• Verfasst von: Shahzad Hussain, Khurrum [VerfasserIn]
• Verfasst von: Isermann, Berend [VerfasserIn]
• Titel: The evolving plasticity of coagulation protease-dependent cytoprotective signalling
• Paralleltitel: Neue Erkenntnisse über die Plastizität der Gerinnungsproteasen-vermittelten Zytoprotektion
• Verf.angabe: K. Shahzad, B. Isermann
• E-Jahr: 2011
• Jahr: {2011]
• Umfang: 6 S.
• Fussnoten: Gesehen am 30.11.2022
• Titel Quelle: Enthalten in: Hämostaseologie
• Ort Quelle: Stuttgart : Thieme, 1981
• Jahr Quelle: 2011
• Band/Heft Quelle: 31(2011), 03, Seite 179-184
• ISSN Quelle: 2567-5761
• DOI: doi:10.5482/ha-1162
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: Shahzad Hussain, Khurrum, 1981 - : The evolving plasticity of coagulation protease-dependent cytoprotective signalling. - 2011
• K10plus-PPN: 1823990215

Abstract

Coagulation proteases control cellular homeostasis beyond haemostasis. While the role of coagulation proteases in regulating vascular healing and thrombosis is well established, the mechanism underlying the receptor-dependent regulation of cellular function remain incompletely understood. In particular, the opposing effects of the protease-activated receptor 1 (PAR-1), dependent on the activating proteases thrombin or activated protein C generated a conundrum researchers only recently have begun to decipher. The net-effect (cellular perturbation vs. cellular protection) depends on co-receptors involved, the concentration of the activating protease, the temporal context of receptor activation, and a dynamic process of receptor rearrangement upon receptor activation. The latter scenario recruits receptors to a cytoprotective signalling pathways. Recent insights into these mechanisms are summarized in this article.