Functional improvement following direct interventional leaflet repair of severe tricuspid regurgitation

• Verfasst von: Volz, Martin J. [VerfasserIn]
• Verfasst von: Hörbrand, Isabel [VerfasserIn]
• Verfasst von: Konstandin, Mathias [VerfasserIn]
• Verfasst von: Mereles, Derliz [VerfasserIn]
• Verfasst von: Weiss, Celine [VerfasserIn]
• Verfasst von: Warnecke, Gregor [VerfasserIn]
• Verfasst von: Frey, Norbert [VerfasserIn]
• Verfasst von: Aurich, Matthias [VerfasserIn]
• Verfasst von: Raake, Philip [VerfasserIn]
• Titel: Functional improvement following direct interventional leaflet repair of severe tricuspid regurgitation
• Verf.angabe: Martin J. Volz, Isabel Hoerbrand, Mathias H. Konstandin, Derliz Mereles, Celine Weiss, Gregor Warnecke, Norbert Frey, Matthias Aurich, Philip W. Raake
• E-Jahr: 2022
• Jahr: 8 February 2022
• Umfang: 8 S.
• Fussnoten: Gesehen am 30.11.2022
• Titel Quelle: Enthalten in: European Society of CardiologyESC heart failure
• Ort Quelle: Chichester : Wiley, 2014
• Jahr Quelle: 2022
• Band/Heft Quelle: 9(2022), 2, Seite 866-873
• ISSN Quelle: 2055-5822
• DOI: doi:10.1002/ehf2.13831
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cardiopulmonary exercise testing
• Sach-SW: Heart failure
• Sach-SW: Percutaneous valve repair
• Sach-SW: Tricuspid valve repair
• K10plus-PPN: 1824045077
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Aims Several new percutaneous tricuspid repair systems have recently been introduced as new treatment options for severe tricuspid regurgitation (TR). Clinical improvement following percutaneous tricuspid valve leaflet repair has been demonstrated by recent studies. A possible impact on exercise capacity has not yet been reported. Methods and results Eleven patients with at least severe TR and successful tricuspid leaflet repair using the PASCAL Ace implant at our cardiology department were included in this analysis. All patients suffered from symptomatic right-sided heart failure with compromised exercise capacity. Cardiopulmonary exercise testing (CPET), clinical, laboratory, and echocardiographic parameters were assessed at baseline and 3 months follow-up. The primary endpoint was the change in maximal oxygen consumption [VO2 max (mL/(min*kg))] at 3 months follow-up. Secondary endpoints included improvement in TR, cardiac biomarkers, and other clinical outcomes. TR severity at 3 months follow-up post-PASCAL Ace implantation was significantly lower than at baseline (P = 0.004). Cardiac biomarkers including high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide as well as right ventricular diameter improved slightly without reaching statistical significance (P = 0.89, P = 0.32, and P = 0.06, respectively). PASCAL Ace implantation resulted in a significant improvement in cardiopulmonary exercise capacity at 3 months follow-up compared with baseline. Mean VO2 max improved from 9.5 ± 2.8 to 11.4 ± 3.4 mL/(min*kg) (P = 0.006), VO2 max per cent predicted from 42 ± 12% to 50 ± 15% (P = 0.004), peak oxygen uptake from 703 ± 175 to 826 ± 198 mL/min (P = 0.004), and O2 pulse per cent predicted from 67 ± 21% to 81 ± 25% (P = 0.011). Other CPET-related outcomes did not show any significant change over time. Conclusions In this single-centre retrospective analysis, direct tricuspid valve leaflet repair using the transcatheter PASCAL Ace implant system was associated with a reduced TR severity and improved cardiopulmonary exercise capacity.