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| Verfasst von: | Rajcsanyi, Luisa Sophie [VerfasserIn]  |
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| | Diebels, Inga [VerfasserIn] |
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| | Pastoors, Lydia [VerfasserIn] |
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| | Kanber, Deniz [VerfasserIn] |
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| | Peters, Triinu [VerfasserIn] |
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| | Volckmar, Anna-Lena [VerfasserIn] |
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| | Zheng, Yiran [VerfasserIn] |
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| | Grosse, Martin [VerfasserIn] |
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| | Dieterich, Christoph [VerfasserIn] |
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| | Hebebrand, Johannes [VerfasserIn] |
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| | Kaiser, Frank [VerfasserIn] |
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| | Horsthemke, Bernhard [VerfasserIn] |
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| | Hinney, Anke [VerfasserIn] |
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| Titel: | Evidence for correlations between BMI-associated SNPs and circRNAs |
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| Verf.angabe: | Luisa Sophie Rajcsanyi, Inga Diebels, Lydia Pastoors, Deniz Kanber, Triinu Peters, Anna-Lena Volckmar, Yiran Zheng, Martin Grosse, Christoph Dieterich, Johannes Hebebrand, Frank J. Kaiser, Bernhard Horsthemke & Anke Hinney |
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| E-Jahr: | 2022 |
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| Jahr: | 25 July 2022 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 05.12.2022 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 12(2022), Artikel-ID 12643, Seite 1-13 |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment of BMI-associated SNPs on circRNA genomic loci in comparison to non-significant variants. Analysis of sex-stratified GWAS data revealed that circRNA genomic loci encompassed more genome-wide significant BMI-SNPs in females than in males. To explore whether the enrichment is restricted to BMI, we investigated nine additional GWAS studies. We showed an enrichment of trait-associated SNPs in circRNAs for four analysed phenotypes (body height, chronic kidney disease, anorexia nervosa and autism spectrum disorder). To analyse the influence of BMI-affecting SNPs on circRNA levels in vitro, we examined rs4752856 located on hsa_circ_0022025. The analysis of heterozygous individuals revealed an increased level of circRNA derived from the BMI-increasing SNP allele. We conclude that genetic variation may affect the BMI partly through circRNAs. |
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| DOI: | doi:10.1038/s41598-022-16495-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41598-022-16495-7 |
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| | Volltext: https://www.nature.com/articles/s41598-022-16495-7 |
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| | DOI: https://doi.org/10.1038/s41598-022-16495-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Gene regulation |
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| | Medical genetics |
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| | Mutation |
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| K10plus-PPN: | 1824428405 |
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| Verknüpfungen: | → Zeitschrift |
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Evidence for correlations between BMI-associated SNPs and circRNAs / Rajcsanyi, Luisa Sophie [VerfasserIn]; 25 July 2022 (Online-Ressource)
