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Verfasst von:Chillon, Thilo Samson [VerfasserIn]   i
 Maares, Maria Henrietta [VerfasserIn]   i
 Demircan, Kamil [VerfasserIn]   i
 Hackler, Julian [VerfasserIn]   i
 Sun, Qian [VerfasserIn]   i
 Heller, Raban [VerfasserIn]   i
 Diegmann, Joachim [VerfasserIn]   i
 Bachmann, Manuel [VerfasserIn]   i
 Moghaddam-Alvandi, Arash [VerfasserIn]   i
 Haase, Hajo [VerfasserIn]   i
 Schomburg, Lutz [VerfasserIn]   i
Titel:Serum free Zinc is associated with vaccination response to SARS-CoV-2
Verf.angabe:Thilo Samson Chillon, Maria Maares, Kamil Demircan, Julian Hackler, Qian Sun, Raban A. Heller, Joachim Diegmann, Manuel Bachmann, Arash Moghaddam, Hajo Haase and Lutz Schomburg
E-Jahr:2022
Jahr:30 June 2022
Umfang:11 S.
Fussnoten:Gesehen am 05.12.2022
Titel Quelle:Enthalten in: Frontiers in immunology
Ort Quelle:Lausanne : Frontiers Media, 2010
Jahr Quelle:2022
Band/Heft Quelle:13(2022), Artikel-ID 906551, Seite 1-11
ISSN Quelle:1664-3224
Abstract:BackgroundZinc (Zn) is an essential trace element with high relevance for the immune system, and its deficiency is associated with elevated infection risk and severe disease course. The association of Zn status with the immune response to SARS-CoV-2 vaccination is unknown.MethodsA cohort of adult health care workers (n=126) received two doses of BNT162B2, and provided up to four serum samples over a time course of 6 months. Total SARS-CoV-2 IgG and neutralizing antibody potency was determined, along with total as well as free Zn concentrations.ResultsThe SARS-CoV-2 antibodies showed the expected rise in response to vaccination, and decreased toward the last sampling point, with highest levels measured three weeks after the second dose. Total serum Zn concentrations were relatively stable over time, and showed no significant association with SARS-CoV-2 antibodies. Baseline total serum Zn concentration and supplemental intake of Zn were both unrelated to the antibody response to SARS-CoV-2 vaccination. Time resolved analysis of free Zn indicated a similar dynamic as the humoral response. A positive correlation was observed between free Zn concentrations and both the induced antibodies and neutralizing antibody potency.ConclusionWhile the biomarkers of Zn status and supplemental Zn intake appeared unrelated to the humoral immune response to SARS-CoV-2 vaccination, the observed correlation of free Zn to the induced antibodies indicates a diagnostic value of this novel biomarker for the immune system.
DOI:doi:10.3389/fimmu.2022.906551
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3389/fimmu.2022.906551
 kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2022.906551
 DOI: https://doi.org/10.3389/fimmu.2022.906551
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1824455739
Verknüpfungen:→ Zeitschrift

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