Chromosomal imbalances in carcinoma showing thymus-like elements (CASTLE)

• Verfasst von: Veits, Lothar [VerfasserIn]
• Verfasst von: Mechtersheimer, Gunhild [VerfasserIn]
• Verfasst von: Steger, Christina [VerfasserIn]
• Verfasst von: Freitag, Jens [VerfasserIn]
• Verfasst von: Mikuz, Gregor [VerfasserIn]
• Verfasst von: Schmid, Kurt W. [VerfasserIn]
• Verfasst von: Hofmann, Walter [VerfasserIn]
• Verfasst von: Schirmacher, Peter [VerfasserIn]
• Verfasst von: Hartmann, Arndt [VerfasserIn]
• Verfasst von: Rieker, Ralf Joachim [VerfasserIn]
• Titel: Chromosomal imbalances in carcinoma showing thymus-like elements (CASTLE)
• Verf.angabe: Lothar Veits, Gunhild Mechtersheimer, Christina Steger, Jens Freitag, Gregor Mikuz, Kurt W. Schmid, Walter Hofmann, Peter Schirmacher, Arndt Hartmann, Ralf J. Rieker
• E-Jahr: 2011
• Jahr: 07 July 2011
• Umfang: 6 S.
• Fussnoten: Gesehen am 07.12.2022
• Titel Quelle: Enthalten in: Virchows Archiv
• Ort Quelle: Berlin : Springer, 1847
• Jahr Quelle: 2011
• Band/Heft Quelle: 459(2011), 2, Seite 221-226
• ISSN Quelle: 1432-2307
• DOI: doi:10.1007/s00428-011-1117-7
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: Veits, Lothar: Chromosomal imbalances in carcinoma showing thymus-like elements (CASTLE). - 2011
• Sach-SW: Carcinoma showing thymus-like elements
• Sach-SW: CASTLE
• Sach-SW: CGH
• Sach-SW: Chromosomal imbalances
• K10plus-PPN: 1826456139

Abstract

Carcinoma showing thymus-like elements (CASTLE) is a rare neoplasm of the thyroid gland resembling lymphoepithelioma-like and squamous cell carcinoma of the thymus and is thought to arise from ectopic thymic tissue within the thyroid gland or rudimentary branchial pouches along the thymic line. Using comparative genomic hybridization (CGH), chromosomal imbalances have been detected in several types of thymomas and thymic carcinomas. To evaluate whether there are hints of an underlying sequence in the pathogenesis of CASTLE analogue to those found in thymomas and thymic carcinomas, we evaluated four of these rare neoplasms for chromosomal imbalances using CGH. The most frequent gains were seen on chromosomal arm 1q (3/4), and losses were most frequently detected on 6p (4/4), 6q (3/4) and 16q (3/4). These CGH data show that CASTLE is characterized by chromosomal imbalances similar to those found in thymomas and thymic carcinomas and indicate a similar sequence in tumour development.