Serum and gene expression profile of cytokines following combination of yoga training and vitamin D supplementation in breast cancer survivors

• Verfasst von: Naderi, Mahdi [VerfasserIn]
• Verfasst von: Kordestani, Hajar [VerfasserIn]
• Verfasst von: Sahebi, Zahra [VerfasserIn]
• Verfasst von: Zare, Vahid Khedmati [VerfasserIn]
• Verfasst von: Amani-Shalamzari, Sadegh [VerfasserIn]
• Verfasst von: Kaviani, Mojtaba [VerfasserIn]
• Verfasst von: Wiskemann, Joachim [VerfasserIn]
• Verfasst von: Shamsi, Mahdieh Molanouri [VerfasserIn]
• Titel: Serum and gene expression profile of cytokines following combination of yoga training and vitamin D supplementation in breast cancer survivors
• Titelzusatz: a randomized controlled trial
• Verf.angabe: Mahdi Naderi, Hajar Kordestani, Zahra Sahebi, Vahid Khedmati Zare, Sadegh Amani-Shalamzari, Mojtaba Kaviani, Joachim Wiskemann and Mahdieh Molanouri Shamsi
• E-Jahr: 2022
• Jahr: 24 March 2022
• Umfang: 11 S.
• Fussnoten: Gesehen am 13.12.2022
• Titel Quelle: Enthalten in: BMC women's health
• Ort Quelle: London : BioMed Central, 2001
• Jahr Quelle: 2022
• Band/Heft Quelle: 22(2022), Artikel-ID 90, Seite 1-11
• ISSN Quelle: 1472-6874
• DOI: doi:10.1186/s12905-022-01671-8
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cd4(+) t-cells
• Sach-SW: exercise
• Sach-SW: fatigue
• Sach-SW: Handgrip strength
• Sach-SW: Hatha yoga
• Sach-SW: impact
• Sach-SW: inflammation
• Sach-SW: muscle
• Sach-SW: Pro-inflammatory cytokines
• Sach-SW: Quality of life
• Sach-SW: quality-of-life
• Sach-SW: ratio
• Sach-SW: strength
• Sach-SW: women
• K10plus-PPN: 1826853537

Abstract

Background: This study aimed to examine the effect of the combination of yoga training with high vitamin D dose supplementation on the expression and systemic levels of inflammatory cytokines and psychophysical status of breast cancer survivors. Methods: Thirty volunteered breast cancer survivors (48 +/- 8 years) were randomly allocated to a high dose (4000 IU) of vitamin D supplementation (HD) group (n = 10), yoga with a high dose of vitamin D (YHD) group (n = 10), and yoga with a low dose (2000 IU) of vitamin D (YLD) group (n = 10). Participants performed the Hatha yoga style for 12 weeks, twice a week. Blood samples, quality of life (QoL) questionnaire, and physical performance tests were taken before and after the intervention. Results: Body fat percentage (eta p(2) = 0.36), handgrip strength (eta p(2) = 0.41) and QoL indicators include global health (eta p(2) = 0.54), functional scales (eta p(2) = 0.49), and symptoms scales (eta p(2) = 0.50) were significantly improved in the both YHD and YLD groups compared to the HD group (p < 0.05). Also, interleukin-10 (IL-10) levels were markedly increased in the Y-HVD group compared to the Y-LVD and HVD groups. Moreover, there were significant decreases in tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 levels in the Y-HVD group after the intervention. The anti-inflammatory index (IL-10/TNF-alpha) was significantly increased in both the yoga groups (P < 0.05). Conclusion: Yoga promotes physical and psychological fitness and, in combination with a high dose of vitamin D, improves the cytokine profile, which can effectively manage the side effects associated with cancer.