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| Verfasst von: | Cumin, Cécile [VerfasserIn]  |
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| | Huang, Yen-Lin [VerfasserIn] |
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| | Rossdam, Charlotte [VerfasserIn] |
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| | Ruoff, Felix [VerfasserIn] |
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| | Céspedes, Susana Posada [VerfasserIn] |
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| | Liang, Ching-Yeu [VerfasserIn] |
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| | Lombardo, Flavio C. [VerfasserIn] |
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| | Coelho, Ricardo [VerfasserIn] |
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| | Rimmer, Natalie [VerfasserIn] |
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| | Konantz, Martina [VerfasserIn] |
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| | López, Mónica Núñez [VerfasserIn] |
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| | Alam, Md Shahidul [VerfasserIn] |
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| | Schmidt, Alexander [VerfasserIn] |
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| | Calabrese, Diego [VerfasserIn] |
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| | Fedier, Andre [VerfasserIn] |
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| | Vlajnic, Tatjana [VerfasserIn] |
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| | von Itzstein, Mark [VerfasserIn] |
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| | Templin, Markus [VerfasserIn] |
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| | Buettner, Falk F. R. [VerfasserIn] |
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| | Everest-Dass, Arun [VerfasserIn] |
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| | Heinzelmann-Schwarz, Viola [VerfasserIn] |
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| | Jacob, Francis [VerfasserIn] |
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| Titel: | Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways |
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| Verf.angabe: | Cécile Cumin, Yen-Lin Huang, Charlotte Rossdam, Felix Ruoff, Susana Posada Céspedes, Ching-Yeu Liang, Flavio C. Lombardo, Ricardo Coelho, Natalie Rimmer, Martina Konantz, Mónica Núñez López, Shahidul Alam, Alexander Schmidt, Diego Calabrese, Andre Fedier, Tatjana Vlajnic, Mark von Itzstein, Markus Templin, Falk F. R. Buettner, Arun Everest-Dass, Viola Heinzelmann-Schwarz, and Francis Jacob |
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| E-Jahr: | 2022 |
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| Jahr: | August 16, 2022 |
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| Umfang: | 16 S. |
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| Fussnoten: | Das PDF enthält zusätzlich einen Anhang von 10 Seiten ; Gesehen am 13.12.2022 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 40(2022), 7, Artikel-ID 111181, Seite 1-16 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | The molecular repertoire promoting cancer cell plasticity is not fully elucidated. Here, we propose that glycosphingolipids (GSLs), specifically the globo and ganglio series, correlate and promote the transition between epithelial and mesenchymal cells. The epithelial character of ovarian cancer remains stable throughout disease progression, and spatial glycosphingolipidomics reveals elevated globosides in the tumor compartment compared with the ganglioside-rich stroma. CRISPR-Cas9 knockin mediated truncation of endogenous E-cadherin induces epithelial-to-mesenchymal transition (EMT) and decreases globosides. The transcriptomics analysis identifies the ganglioside-synthesizing enzyme ST8SIA1 to be consistently elevated in mesenchymal-like samples, predicting poor outcome. Subsequent deletion of ST8SIA1 induces epithelial cell features through mTORS2448 phosphorylation, whereas loss of globosides in ΔA4GALT cells, resulting in EMT, is accompanied by increased ERKY202/T204 and AKTS124. The GSL composition dynamics corroborate cancer cell plasticity, and further evidence suggests that mesenchymal cells are maintained through ganglioside-dependent, calcium-mediated mechanisms. |
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| DOI: | doi:10.1016/j.celrep.2022.111181 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.celrep.2022.111181 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722009949 |
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| | DOI: https://doi.org/10.1016/j.celrep.2022.111181 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | calcium |
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| | EMT |
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| | gangliosides |
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| | globosides |
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| | MALDI imaging |
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| | MET |
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| | ovarian cancer |
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| | sialic acid |
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| | signaling pathways |
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| K10plus-PPN: | 1826854339 |
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| Verknüpfungen: | → Zeitschrift |
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Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways / Cumin, Cécile [VerfasserIn]; August 16, 2022 (Online-Ressource)
