Vitamin D-binding protein, bioavailable, and free 25(OH)D, and mortality

• Verfasst von: Zhu, Anna [VerfasserIn]
• Verfasst von: Kuznia, Sabine [VerfasserIn]
• Verfasst von: Boakye, Daniel [VerfasserIn]
• Verfasst von: Schöttker, Ben [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Titel: Vitamin D-binding protein, bioavailable, and free 25(OH)D, and mortality
• Titelzusatz: a systematic review and meta-analysis
• Verf.angabe: Anna Zhu, Sabine Kuznia, Daniel Boakye, Ben Schöttker and Hermann Brenner
• E-Jahr: 2022
• Jahr: 20 September 2022
• Umfang: 15 S.
• Fussnoten: Gesehen am 13.12.2022
• Titel Quelle: Enthalten in: Nutrients
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2022
• Band/Heft Quelle: 14(2022), 19, Artikel-ID 3894, Seite 1-15
• ISSN Quelle: 2072-6643
• DOI: doi:10.3390/nu14193894
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: bioavailable 25(OH)D
• Sach-SW: free 25(OH)D
• Sach-SW: meta-analysis
• Sach-SW: mortality
• Sach-SW: systematic review
• Sach-SW: vitamin D-binding protein (VDBP)
• K10plus-PPN: 1826877592

Abstract

Introduction: Observational studies reported inverse associations between serum total 25-hydroxyvitamin D (25(OH)D) concentrations and mortality. Evolving evidence indicated, however, that bioavailable or free 25(OH)D may be even better predictors of mortality. We conducted a systematic review and meta-analysis to summarize the epidemiological evidence on associations of vitamin D-binding protein (VDBP), albumin-bound, bioavailable, and free 25(OH)D, with mortality. Methods: We systematically searched PubMed and Web of Science, up to 27 May 2022. Predictors of interest included serum or plasma concentrations of VDBP, albumin-bound, bioavailable, and free 25(OH)D. Assessed health outcomes were all-cause and cause-specific mortality. We included studies reporting associations between these biomarkers and mortality outcomes. We applied random-effects models for meta-analyses to summarize results from studies assessing the same vitamin D biomarkers and mortality outcomes. Results: We identified twelve eligible studies, including ten on VDBP, eight on bioavailable 25(OH)D, and eight on free 25(OH)D. No study reported on albumin-bound 25(OH)D and mortality. In meta-analyses, the highest levels of bioavailable and free 25(OH)D were associated with 37% (hazard ratio (HR): 0.63, 95% confidence interval (CI): 0.46, 0.87), and 29% (HR: 0.71, 95% CI: 0.53, 0.97) decrease in all-cause mortality, respectively, compared with the lowest levels. These estimates were similar to those for total 25(OH)D (HR: 0.67, 95% CI: 0.56, 0.80) observed in the same studies. Higher VDBP levels were associated with lower all-cause mortality in cancer patient cohorts. However, no such association was observed in general population cohorts. Conclusions: Similar inverse associations of total, bioavailable, and free 25(OH)D with mortality suggest that bioavailable and free 25(OH)D do not provide incremental value in predicting mortality.