Advanced glycation end-products are associated with diabetic neuropathy in young adults with type 1 diabetes

• Verfasst von: Al-Saoudi, Elaf [VerfasserIn]
• Verfasst von: Christensen, Marie M. B. [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Verfasst von: Fleming, Thomas [VerfasserIn]
• Verfasst von: Hommel, Eva E. [VerfasserIn]
• Verfasst von: Jørgensen, Marit E. [VerfasserIn]
• Verfasst von: Fleischer, Jesper [VerfasserIn]
• Verfasst von: Hansen, Christian S. [VerfasserIn]
• Titel: Advanced glycation end-products are associated with diabetic neuropathy in young adults with type 1 diabetes
• Verf.angabe: Elaf Al-Saoudi, Marie M. B. Christensen, Peter Nawroth, Thomas Fleming, Eva E. Hommel, Marit E. Jørgensen, Jesper Fleischer and Christian S. Hansen
• E-Jahr: 2022
• Jahr: 11 October 2022
• Umfang: 13 S.
• Fussnoten: Gesehen am 13.12.2022
• Titel Quelle: Enthalten in: Frontiers in endocrinology
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2010
• Jahr Quelle: 2022
• Band/Heft Quelle: 13(2022), Artikel-ID 891442, Seite 1-13
• ISSN Quelle: 1664-2392
• DOI: doi:10.3389/fendo.2022.891442
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1826927166

Abstract

Aims/hypothesisAdvanced glycation end-products (AGEs) may contribute to the development of diabetic neuropathy. In young adults with type 1 diabetes, we aimed to investigate the association between AGEs and cardiovascular autonomic neuropathy (CAN) and distal symmetric polyneuropathy (DSPN).MethodsThis cross-sectional study comprised 151 young adults. CAN was assessed by cardiovascular autonomic reflex tests; lying-to-standing test, deep breathing test (E/I), Valsalva manoeuvre, and heart rate variability indices; and the mean square of the sum of the squares of differences between consecutive R-R intervals and standard deviation of normal-to-normal intervals (SDNN), high- (HF) and low-frequency (LF) power, total frequency power, and the LF/HF ratio. DSPN was assessed by light touch, pain and vibration perception threshold (VPT), neuropathy questionnaires, and objective measures. AGEs were analysed in four groups using z-scores adjusted for relevant confounders and multiple testing: i) “glycolytic dysfunction”, ii) “lipid peroxidation”, iii) “oxidative stress”, and iv) “glucotoxicity”.ResultsA higher z-score of “glycolytic dysfunction” was associated with higher VPT (4.14% (95% CI 1.31; 7.04), p = 0.004) and E/I (0.03% (95% CI 0.01; 0.05), p = 0.005), “lipid peroxidation” was associated with higher LF/HF ratio (37.72% (95% CI 1.12; 87.57), p = 0.044), and “glucotoxicity” was associated with lower SDNN (−4.20% (95% CI −8.1416; −0.0896), p = 0.047). No significance remained after adjustment for multiple testing.Conclusions/interpretationsIn young adults with type 1 diabetes, increased levels of AGEs involving different metabolic pathways were associated with several measures of CAN and DSPN, suggesting that AGEs may play a diverse role in the pathogeneses of diabetic neuropathy.