Proximal neuropathic lesions in distal symmetric diabetic polyneuropathy

• Verfasst von: Pham, Mirko [VerfasserIn]
• Verfasst von: Oikonomou, Dimitrios [VerfasserIn]
• Verfasst von: Bäumer, Philipp [VerfasserIn]
• Verfasst von: Bierhaus, Angelika [VerfasserIn]
• Verfasst von: Heiland, Sabine [VerfasserIn]
• Verfasst von: Humpert, Per Magnus [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Titel: Proximal neuropathic lesions in distal symmetric diabetic polyneuropathy
• Titelzusatz: findings of high-resolution magnetic resonance neurography
• Verf.angabe: Mirko Pham, Dimitrios Oikonomou, Philipp Bäumer, Angelika Bierhaus, Sabine Heiland, Per M. Humpert, Peter P. Nawroth, Martin Bendszus
• E-Jahr: 2011
• Jahr: February 17, 2011
• Umfang: 3 S.
• Fussnoten: Gesehen am 14.12.2022
• Titel Quelle: Enthalten in: Diabetes care
• Ort Quelle: Alexandria, Va. : Assoc., 1978
• Jahr Quelle: 2011
• Band/Heft Quelle: 34(2011), 3, Seite 721-723
• ISSN Quelle: 1935-5548
• DOI: doi:10.2337/dc10-1491
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Aged
• Sach-SW: Diabetic Neuropathies
• Sach-SW: Female
• Sach-SW: Humans
• Sach-SW: Magnetic Resonance Imaging
• Sach-SW: Male
• Sach-SW: Middle Aged
• Sach-SW: Polyneuropathies
• K10plus-PPN: 1827020822

Abstract

OBJECTIVE: This study investigated high-resolution magnetic resonance neurography (MRN) in distal symmetric diabetic polyneuropathy (dPNP). - RESEARCH DESIGN AND METHODS: MRN comprised high-resolution transaxial imaging of peripheral nerves of the lower limbs in 20 patients with type 2 diabetes (10 with dPNP, type 2/dPNP[+], and 10 without dPNP, type 2/dPNP[-]), seven patients with type 1 diabetes (two with dPNP, type 1/dPNP[+], five without dPNP, type 1/dPNP[-]), and 10 nondiabetic control subjects. Intraneural T2 lesions, as the main diagnostic criterion of MRN, were detected visually by two independent observers and quantitatively by analysis of T2 contrast ratios. - RESULTS: Multifocal fascicular, symmetric intraneural T2 lesions occurred in the proximal trunks of sciatic nerves in four patients (three with type 2/dPNP[+] and one with type 1/dPNP[+]) but not in control subjects (type 2/dPNP[-], type 1/dPNP[-], nondiabetic control subjects), which was confirmed by quantitative analysis. Clinical severity was higher in patients with T2 lesions (neuropathy deficit score: 10 vs. 7.8; P = 0.05). - CONCLUSIONS: For the first time, proximal neuropathic lesions of dPNP are reported in vivo. This supports that accumulation of proximal, multifocal fascicular injury may be important in disease progression.