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Verfasst von:Pilz, Stefan [VerfasserIn]   i
 Meinitzer, Andreas [VerfasserIn]   i
 Tomaschitz, Andreas [VerfasserIn]   i
 Drechsler, Christiane [VerfasserIn]   i
 Ritz, Eberhard [VerfasserIn]   i
 Krane, Vera [VerfasserIn]   i
 Wanner, Christoph [VerfasserIn]   i
 Boehm, Bernhard O. [VerfasserIn]   i
 März, Winfried [VerfasserIn]   i
Titel:Low homoarginine concentration is a novel risk factor for heart disease
Verf.angabe:Stefan Pilz, Andreas Meinitzer, Andreas Tomaschitz, Christiane Drechsler, Eberhard Ritz, Vera Krane, Christoph Wanner, Bernhard O. Boehm, Winfried März
E-Jahr:2011
Jahr:July 07, 2011
Umfang:6 S.
Fussnoten:Gesehen am 14.12.2022
Titel Quelle:Enthalten in: Heart
Ort Quelle:[London] : BMJ Publ. Group, 1996
Jahr Quelle:2011
Band/Heft Quelle:97(2011), 15, Seite 1222-1227
ISSN Quelle:1468-201X
Abstract:BACKGROUND: Homoarginine is an amino acid which may play a role in nitric oxide and energy metabolism. Low homoarginine concentrations have previously been linked to increased mortality, but the underlying mechanisms remain unknown. - OBJECTIVES: To investigate whether serum homoarginine concentrations are associated with myocardial function, energy metabolism and fatal events. - DESIGN AND PATIENTS: Serum homoarginine concentrations were measured in 3305 Caucasian patients who were referred for coronary angiography at a tertiary care centre in Germany. After baseline examinations (1997-2000), patients were followed-up with respect to specific causes of death. - RESULTS: Homoarginine concentration correlated positively with angiographic ejection fraction and was inversely associated with N-terminal pro-B-type natriuretic peptide (p<0.001 for both). Variables of energy metabolism (guanidinoacetate and creatine) were significantly associated with homoarginine concentration (p<0.001 for both). Over a median follow-up time of 9.9 years, 991 patients died, including 258 sudden cardiac deaths, 148 heart failure deaths and 105 fatal myocardial infarctions. Multivariable adjusted Cox proportional HRs (with 95% CI) for the first versus the fourth homoarginine quartile were 2.44 (1.60 to 3.73) for sudden cardiac deaths, 3.44 (1.89 to 6.24) for heart failure deaths, and 3.78 (1.77 to 8.06) for fatal myocardial infarctions. - CONCLUSIONS: Homoarginine deficiency is associated with myocardial dysfunction and significantly increased risk of fatal cardiovascular events and may be related to poor energy metabolism. Further studies are warranted to explore the significance of homoarginine metabolism in risk stratification and treatment of heart diseases.
DOI:doi:10.1136/hrt.2010.220731
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1136/hrt.2010.220731
 DOI: https://doi.org/10.1136/hrt.2010.220731
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Biomarkers
 Chromatography, High Pressure Liquid
 Coronary Angiography
 Creatinine
 Cross-Sectional Studies
 Energy Metabolism
 Female
 Follow-Up Studies
 Germany
 Glycine
 Heart Diseases
 Homoarginine
 Humans
 Incidence
 Male
 Middle Aged
 Myocardium
 Prognosis
 Proportional Hazards Models
 Retrospective Studies
 Risk Factors
 Severity of Illness Index
 Survival Rate
 Time Factors
K10plus-PPN:1827049383
Verknüpfungen:→ Zeitschrift

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