Vitamin D status and mortality in chronic kidney disease

• Verfasst von: Pilz, Stefan [VerfasserIn]
• Verfasst von: Tomaschitz, Andreas [VerfasserIn]
• Verfasst von: Friedl, Claudia [VerfasserIn]
• Verfasst von: Amrein, Karin [VerfasserIn]
• Verfasst von: Drechsler, Christiane [VerfasserIn]
• Verfasst von: Ritz, Eberhard [VerfasserIn]
• Verfasst von: Boehm, Bernhard O. [VerfasserIn]
• Verfasst von: Grammer, Tanja B. [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: Vitamin D status and mortality in chronic kidney disease
• Verf.angabe: Stefan Pilz, Andreas Tomaschitz, Claudia Friedl, Karin Amrein, Christiane Drechsler, Eberhard Ritz, Bernhard O. Boehm, Tanja B. Grammer and Winfried März
• E-Jahr: 2011
• Jahr: 4 March 2011
• Umfang: 7 S.
• Fussnoten: Gesehen am 14.12.2022
• Titel Quelle: Enthalten in: Nephrology, dialysis, transplantation
• Ort Quelle: Oxford : Oxford Univ. Press, 1986
• Jahr Quelle: 2011
• Band/Heft Quelle: 26(2011), 11, Seite 3603-3609
• ISSN Quelle: 1460-2385
• DOI: doi:10.1093/ndt/gfr076
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Ergänzung: Ring, Troels: Vitamin D and nephrology
• Sach-SW: Aged
• Sach-SW: Cardiovascular Diseases
• Sach-SW: Coronary Angiography
• Sach-SW: Female
• Sach-SW: Follow-Up Studies
• Sach-SW: Glomerular Filtration Rate
• Sach-SW: Humans
• Sach-SW: Kidney Failure, Chronic
• Sach-SW: Male
• Sach-SW: Prognosis
• Sach-SW: Prospective Studies
• Sach-SW: Risk Factors
• Sach-SW: Survival Rate
• Sach-SW: Vitamin D
• Sach-SW: Vitamin D Deficiency
• K10plus-PPN: 1827050489

Abstract

BACKGROUND: Vitamin D deficiency is found in the majority of patients with chronic kidney disease (CKD) and may contribute to various chronic diseases. Current guidelines suggest correcting reduced 25-hydroxyvitamin D [25(OH)D] concentrations in CKD patients with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2). Whether low 25(OH)D levels in these patients are associated with higher mortality is unclear. This issue was addressed in the present work. - METHODS: We examined 444 patients with eGFR <60 mL/min/1.73 m(2) from the Ludwigshafen Risk and Cardiovascular Health Study. This prospective cohort study includes Caucasian patients without primary kidney disease who were routinely referred to coronary angiography at baseline (1997-2000). - RESULTS: During a median follow-up time of 9.4 years, 227 patients died including 159 deaths from cardiovascular causes. Multivariate adjusted hazard ratios (HRs) (with 95% confidence intervals) in severely vitamin D-deficient [25(OH)D <10 ng/mL] compared to vitamin D-sufficient patients [25(OH)D ≥ 30 ng/mL] were 3.79 (1.71-8.43) for all-cause and 5.61 (1.89-16.6) for cardiovascular mortality. Adjusted HRs per 10 ng/mL increase in 25(OH)D levels were 0.63 (0.50-0.79) for all-cause and 0.59 (0.45-0.79) for cardiovascular mortality. There was no significant interaction with parathyroid hormone concentrations. - CONCLUSIONS: Low 25(OH)D levels are associated with increased all-cause and cardiovascular mortality in CKD patients. These findings support suggestions to correct vitamin D deficiency, but whether vitamin D supplementation improves survival remains to be proven in randomized controlled trials.