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| Verfasst von: | Pilz, Stefan [VerfasserIn]  |
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| | Tomaschitz, Andreas [VerfasserIn] |
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| | Meinitzer, Andreas [VerfasserIn] |
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| | Drechsler, Christiane [VerfasserIn] |
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| | Ritz, Eberhard [VerfasserIn] |
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| | Krane, Vera [VerfasserIn] |
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| | Wanner, Christoph [VerfasserIn] |
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| | Böhm, Bernhard O. [VerfasserIn] |
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| | März, Winfried [VerfasserIn] |
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| Titel: | Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography |
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| Verf.angabe: | Stefan Pilz MD, Andreas Tomaschitz MD, Andreas Meinitzer PhD, Christiane Drechsler MD, PhD,Eberhard Ritz MD, Vera Krane MD, Christoph Wanner MD, Bernhard O. Böhm MD, Winfried März MD |
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| E-Jahr: | 2011 |
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| Jahr: | 10 February 2011 |
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| Umfang: | 3 S. |
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| Fussnoten: | Gesehen am 15.12.2022 |
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| Titel Quelle: | Enthalten in: Stroke |
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| Ort Quelle: | New York, NY : Association, 1970 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 42(2011), 4, Seite 1132-1134 |
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| ISSN Quelle: | 1524-4628 |
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| Abstract: | BACKGROUND AND PURPOSE: Low serum concentrations of the amino acid homoarginine have been associated with endothelial dysfunction and an increased risk of all-cause and cardiovascular mortality. We aimed to investigate whether homoarginine levels are also associated with fatal strokes and a history of nonfatal cerebrovascular disease. - METHODS: Serum homoarginine was measured in 3305 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study who were referred to coronary angiography at baseline (1997 to 2000) and were followed up with respect to mortality. - RESULTS: During a median follow-up time of 9.9 years, 991 patients died including 61 fatal (ischemic and hemorrhagic) strokes. In a binary logistic regression analysis, the odds ratio (with 95% CI) for fatal stroke per SD of homoarginine was 0.52 (0.37 to 0.73; P<0.001) and remained significant after multivariable adjustments (0.62 [0.42 to 0.91]; P=0.014). For previous cerebrovascular disease events, the multivariable adjusted OR per SD of homoarginine was 0.82 (0.70 to 0.96; P=0.014). - CONCLUSIONS: Low homoarginine levels are a novel risk factor for fatal strokes and are reduced in patients with a history of cerebrovascular disease. Further studies are needed to explore the significance of homoarginine to risk stratification and therapeutic approaches in the prevention of strokes. |
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| DOI: | doi:10.1161/STROKEAHA.110.603035 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1161/STROKEAHA.110.603035 |
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| | DOI: https://doi.org/10.1161/STROKEAHA.110.603035 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Aged |
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| | Biomarkers |
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| | Comorbidity |
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| | Coronary Angiography |
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| | Coronary Artery Disease |
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| | Endothelial Cells |
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| | Female |
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| | Follow-Up Studies |
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| | Homoarginine |
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| | Humans |
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| | Male |
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| | Middle Aged |
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| | Mortality |
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| | Risk Factors |
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| | Stroke |
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| | Time Factors |
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| K10plus-PPN: | 1827173939 |
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| Verknüpfungen: | → Zeitschrift |
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Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography / Pilz, Stefan [VerfasserIn]; 10 February 2011 (Online-Ressource)
