| |  Online-Ressource |
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| Verfasst von: | Yurlova, Larisa [VerfasserIn]  |
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| | Kahya, Nicoletta [VerfasserIn] |
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| | Aggarwal, Shweta [VerfasserIn] |
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| | Kaiser, Hermann-Josef [VerfasserIn] |
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| | Chiantia, Salvatore [VerfasserIn] |
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| | Bakhti, Mostafa [VerfasserIn] |
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| | Pewzner-Jung, Yael [VerfasserIn] |
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| | Ben-David, Oshrit [VerfasserIn] |
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| | Futerman, Anthony H. [VerfasserIn] |
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| | Brügger, Britta [VerfasserIn] |
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| | Simons, Mikael [VerfasserIn] |
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| Titel: | Self-segregation of myelin membrane lipids in model membranes |
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| Verf.angabe: | Larisa Yurlova, Nicoletta Kahya, Shweta Aggarwal, Hermann-Josef Kaiser, Salvatore Chiantia, Mostafa Bakhti, Yael Pewzner-Jung, Oshrit Ben-David, Anthony H. Futerman, Britta Brügger, and Mikael Simons |
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| E-Jahr: | 2011 |
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| Jahr: | 6 December 2011 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 19.12.2022 |
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| Titel Quelle: | Enthalten in: Biophysical journal |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 1960 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 101(2011), 11, Seite 2713-2720 |
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| ISSN Quelle: | 1542-0086 |
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| Abstract: | Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are multilamellar, lipid-rich membranes produced by oligodendrocytes in the central nervous system. To act as an insulator, myelin has to form a stable and firm membrane structure. In this study, we have analyzed the biophysical properties of myelin membranes prepared from wild-type mice and from mouse mutants that are unable to form stable myelin. Using C-Laurdan and fluorescence correlation spectroscopy, we find that lipids are tightly organized and highly ordered in myelin isolated from wild-type mice, but not from shiverer and ceramide synthase 2 null mice. Furthermore, only myelin lipids from wild-type mice laterally segregate into physically distinct lipid phases in giant unilamellar vesicles in a process that requires very long chain glycosphingolipids. Taken together, our findings suggest that oligodendrocytes exploit the potential of lipids to self-segregate to generate a highly ordered membrane for electrical insulation of axons. |
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| DOI: | doi:10.1016/j.bpj.2011.10.026 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.bpj.2011.10.026 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0006349511012471 |
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| | DOI: https://doi.org/10.1016/j.bpj.2011.10.026 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1827854227 |
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| Verknüpfungen: | → Zeitschrift |
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Self-segregation of myelin membrane lipids in model membranes / Yurlova, Larisa [VerfasserIn]; 6 December 2011 (Online-Ressource)
