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Verfasst von:Bösing, Christoph [VerfasserIn]   i
 Graf, Peter Tobias [VerfasserIn]   i
 Thiel, Manfred [VerfasserIn]   i
 Lücke, Thomas [VerfasserIn]   i
 Krebs, Jörg [VerfasserIn]   i
Titel:Procollagen I and III as prognostic markers in patients treated with extracorporeal membrane oxygenation
Titelzusatz:a prospective observational study
Verf.angabe:Christoph Boesing, Peter T. Graf, Manfred Thiel, Thomas Luecke and Joerg Krebs
E-Jahr:2021
Jahr:19 August 2021
Umfang:14 S.
Fussnoten:Published: 19 August 2021 ; Gesehen am 19.12.2022
Titel Quelle:Enthalten in: Journal of Clinical Medicine
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2021
Band/Heft Quelle:10(2021), 16, Artikel-ID 3686, Seite 1-14
ISSN Quelle:2077-0383
Abstract:Background: Procollagen peptides have been associated with lung fibroproliferation and poor outcomes in patients with acute respiratory distress syndrome (ARDS). Therefore, serum procollagen concentrations might have prognostic value in ARDS patients treated with extracorporeal membrane oxygenation (ECMO). Methods: In a prospective cohort study, serum N-terminal procollagen I-peptide (PINP) and N-terminal procollagen III-peptide (PIIINP) concentrations in twenty-three consecutive patients with severe ARDS treated with ECMO were measured at the time of ECMO initiation and during the course of treatment. The predictive value of PINP and PIIINP at the time of ECMO initiation was tested with a univariable logistic regression and a receiver operating characteristic (ROC) curve analysis. Results: Thirteen patients survived to intensive care unit (ICU) discharge. Non-survivors had higher serum PINP and PIIINP concentrations at all points in time during the course of treatment. Serum PIIINP at the day of ECMO initiation showed an odds ratio of 1.37 (95% CI 1.10-1.89, p = 0.017) with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.87 (95% CI 0.69-1.00, p = 0.0029) for death during the course of treatment. Conclusions: PINP and PIIINP concentrations differ between survivors and non-survivors in ARDS treated with ECMO. This exploratory hypothesis generating study suggests an association between PIIINP serum concentrations at ECMO initiation and an unfavorable clinical outcome.
DOI:doi:10.3390/jcm10163686
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/jcm10163686
 Volltext: https://www.mdpi.com/2077-0383/10/16/3686
 DOI: https://doi.org/10.3390/jcm10163686
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:acute respiratory distress syndrome
 extracorporeal membrane oxygenation
 procollagen I
 procollagen III
K10plus-PPN:1827864125
Verknüpfungen:→ Zeitschrift

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