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| Verfasst von: | Kokate, Shrikant B. [VerfasserIn]  |
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| | Ciuba, Katarzyna [VerfasserIn] |
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| | Tran, Vivien D. [VerfasserIn] |
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| | Kumari, Reena [VerfasserIn] |
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| | Tojkander, Sari [VerfasserIn] |
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| | Engel, Ulrike [VerfasserIn] |
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| | Kogan, Konstantin [VerfasserIn] |
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| | Kumar, Sanjay [VerfasserIn] |
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| | Lappalainen, Pekka [VerfasserIn] |
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| Titel: | Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments |
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| Verf.angabe: | Shrikant B. Kokate, Katarzyna Ciuba, Vivien D. Tran, Reena Kumari, Sari Tojkander, Ulrike Engel, Konstantin Kogan, Sanjay Kumar & Pekka Lappalainen |
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| E-Jahr: | 2022 |
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| Jahr: | 13 October 2022 |
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| Umfang: | 20 S. |
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| Fussnoten: | Gesehen am 19.12.2022 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 13(2022), Artikel-ID 6032, Seite 1-20 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Contractile actomyosin bundles are key force-producing and mechanosensing elements in muscle and non-muscle tissues. Whereas the organization of muscle myofibrils and mechanism regulating their contractility are relatively well-established, the principles by which myosin-II activity and force-balance are regulated in non-muscle cells have remained elusive. We show that Caldesmon, an important component of smooth muscle and non-muscle cell actomyosin bundles, is an elongated protein that functions as a dynamic cross-linker between myosin-II and tropomyosin-actin filaments. Depletion of Caldesmon results in aberrant lateral movement of myosin-II filaments along actin bundles, leading to irregular myosin distribution within stress fibers. This manifests as defects in stress fiber network organization and contractility, and accompanied problems in cell morphogenesis, migration, invasion, and mechanosensing. These results identify Caldesmon as critical factor that ensures regular myosin-II spacing within non-muscle cell actomyosin bundles, and reveal how stress fiber networks are controlled through dynamic cross-linking of tropomyosin-actin and myosin filaments. |
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| DOI: | doi:10.1038/s41467-022-33688-w |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext ; Verlag: https://doi.org/10.1038/s41467-022-33688-w |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-022-33688-w |
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| | DOI: https://doi.org/10.1038/s41467-022-33688-w |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cell invasion |
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| | Myosin |
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| | Stress fibres |
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| K10plus-PPN: | 1827895926 |
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| Verknüpfungen: | → Zeitschrift |
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Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments / Kokate, Shrikant B. [VerfasserIn]; 13 October 2022 (Online-Ressource)
