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Status: Bibliographieeintrag

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Verfasst von:Yang, Dongyun [VerfasserIn]   i
 Strobel, Tobias [VerfasserIn]   i
 Bulkescher, Julia [VerfasserIn]   i
 Teßmer, Claudia [VerfasserIn]   i
 Hofmann, Ilse [VerfasserIn]   i
 Hoppe-Seyler, Felix [VerfasserIn]   i
 Hoppe-Seyler, Karin [VerfasserIn]   i
Titel:FAM57A (family with sequence similarity 57 member A) is a cell-density-regulated protein and promotes the proliferation and migration of cervical cancer cells
Verf.angabe:Dongyun Yang, Tobias D. Strobel, Julia Bulkescher, Claudia Tessmer, Ilse Hofmann, Felix Hoppe-Seyler and Karin Hoppe-Seyler
E-Jahr:2022
Jahr:21 October 2022
Umfang:15 S.
Fussnoten:Gesehen am 20.12.2022
Titel Quelle:Enthalten in: Cells
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2022
Band/Heft Quelle:11(2022), 20 vom: Okt., Artikel-ID 3309, Seite 1-15
ISSN Quelle:2073-4409
Abstract:The FAM57A (family with sequence similarity 57 member A) gene is controversially discussed to possess pro- or anti-tumorigenic potential. Here, we analyze the regulation of cellular FAM57A protein levels and study the functional role of FAM57A in HPV-positive cervical cancer cells. We find that FAM57A protein expression strongly depends on cell density, with FAM57A being readily detectable at low cell density, but undetectable at high cell density. This regulation occurs post-transcriptionally and is not mirrored by corresponding changes at the RNA level. We further show that FAM57A protein levels are highly increased in cervical cancer cells cultivated at hypoxia compared to normoxia and provide evidence that FAM57A is a hypoxia-responsive gene under control of the α-subunit of the HIF-1 (hypoxia-inducible factor-1) transcription factor. Yet, the strong relative increase of FAM57A protein levels in hypoxic cells is predominantly cell-density-dependent and occurs post-transcriptionally. Other anti-proliferative effectors besides hypoxia, such as silencing of HPV E6/E7 oncogene expression in cervical cancer cells, also result in an increase of FAM57A levels compared to untreated cells. Functional analyses reveal that FAM57A repression leads to pronounced anti-proliferative as well as anti-migratory effects in cervical cancer cells. Taken together, these results provide insights into the regulation of FAM57A protein levels and reveal that they underlie a tight cell-density-dependent control. Moreover, they identify FAM57A as a critical determinant for the phenotype of cervical cancer cells, which promotes their proliferation and migration capacities.
DOI:doi:10.3390/cells11203309
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/cells11203309
 Volltext: https://www.mdpi.com/2073-4409/11/20/3309
 DOI: https://doi.org/10.3390/cells11203309
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:<i>FAM57A</i>
 cervical cancer
 human papillomavirus (HPV)
 hypoxia
K10plus-PPN:1828100722
Verknüpfungen:→ Zeitschrift

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