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Verfasst von:Plaschke, Konstanze [VerfasserIn]   i
 Bergmann, Marion [VerfasserIn]   i
 Kopitz, Jürgen [VerfasserIn]   i
Titel:Ginkgo extract EGb 761 shields from slowly accumulating neurodegenerative-like changes in a newly developed cell culture model induced by the combined action of low doses of antimycin A1 and 2-deoxy-D-glucose
Verf.angabe:Konstanze Plaschke, Marion Bergmann, Jürgen Kopitz
E-Jahr:2011
Jahr:9 April 2011
Umfang:8 S.
Fussnoten:Gesehen am 21.12.2022
Titel Quelle:Enthalten in: Journal of neural transmission
Ort Quelle:Wien [u.a.] : Springer, 1950
Jahr Quelle:2011
Band/Heft Quelle:118(2011), 8, Seite 1247-1254
ISSN Quelle:1435-1463
Abstract:Different cell culture models were already used to analyze the molecular base of the neuroprotective activities of the Ginkgo biloba extract EGb 761(®) after a single or short-term application. In these previous studies cells were severely injured with agents that promptly induce fatal cellular damage, like vast oxidative stress or mitochondrial dysfunction, and the protective effects of EGb 761(®) on such acute damage were evaluated. Our present study aimed to test EGb 761(®) action in cell cultures, where cellular functions are only moderately impaired by a longer lasting, but relatively modest oxidative stress, reduction of mitochondrial function and reduced intracellular energy levels, thereby causing only slow occurence of cellular damage over a time period of 2 weeks. To this end we used neuroblastoma cells (SK-N-MC) that were treated with low doses of a combination of antimycin A1 and 2-deoxy-D: -glucose. Addition of EGb 761(®) to the culture medium efficiently shielded the cells from progressing injury by reduced ATP-levels, oxidized redox state, lipid peroxidation damage and oxidative damage of mitochondrial DNA. As a result the cells were protected from apoptotic death that was observed in cultures without EGb 761(®) after 2 weeks of damage occurence. This cell culture system characterizing moderate cellular stress will be applied in future studies to further investigate the mode of action of single EGb 761(®) compounds.
DOI:doi:10.1007/s00702-011-0637-2
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00702-011-0637-2
 DOI: https://doi.org/10.1007/s00702-011-0637-2
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Humans
 Oxidative Stress
 Cell Culture Techniques
 Cell Line, Tumor
 Time Factors
 Plant Extracts
 Drug Therapy, Combination
 Neuroprotective Agents
 Nerve Degeneration
 Antimycin A
 Deoxyglucose
 Ginkgo biloba
K10plus-PPN:1828224979
Verknüpfungen:→ Zeitschrift

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