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Status: Bibliographieeintrag

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Verfasst von:Pleger, Sven Torsten [VerfasserIn]   i
 Mereles, Derliz [VerfasserIn]   i
 Schulz-Schönhagen, Marius [VerfasserIn]   i
 Krumsdorf, Ulrike [VerfasserIn]   i
 Chorianopoulos, Emmanuel [VerfasserIn]   i
 Rottbauer, Wolfgang [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
 Bekeredjian, Raffi [VerfasserIn]   i
Titel:Acute safety and 30-day outcome after percutaneous edge-to-edge repair of mitral regurgitation in very high-risk patients
Verf.angabe:Sven T. Pleger, MD, Derliz Mereles, MD, Marius Schulz-Schönhagen, MS, Ulrike Krumsdorf, MD, Emmanuel Chorianopoulos, MD, Wolfgang Rottbauer, MD, Hugo A. Katus, MD, and Raffi Bekeredjian, MD
E-Jahr:2011
Jahr:3 September 2011
Umfang:5 S.
Fussnoten:Gesehen am 21.12.2022
Titel Quelle:Enthalten in: The American journal of cardiology
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1958
Jahr Quelle:2011
Band/Heft Quelle:108(2011), 10, Seite 1478-1482
ISSN Quelle:1879-1913
Abstract:Percutaneous edge-to-edge mitral valve repair using the MitraClip device has evolved as a new tool for the treatment of severe mitral valve regurgitation. This technique has been evaluated in surgical low- and high-risk patients. Patients with advanced age, multiple morbidities, and heart failure will be the first to be considered for a nonsurgical approach. Thus safety and feasibility data in very high-risk patients are crucial for clinical decision making. The aim of this study was to assess short-term safety and clinical efficacy in high-risk patients with a Society of Thoracic Surgeons (STS) score >15% after MitraClip implantation (mean STS score 24 ± 4%). All relevant complications, mortality, echocardiographic improvement, and changes in brain natriuretic peptide, high-sensitive troponin T, 6-minute walk distance test, and New York Heart Association functional class were collected in patients within 30 days after MitraClip implantation. Mitral regurgitation had significantly decreased after 30 days from grade 2.9 ± 0.2 to 1.7 ± 0.7 (p < 0.0001). Accordingly, New York Heart Association functional class had significantly improved from 3.38 ± 0.59 to 2.2 ± 0.4 (p <0.001). Objective parameters of clinical improvement showed a significant increase in 6-minute walk distance test (from 194 ± 44 to 300 ± 70 m, p <0.01) and insignificant trends in brain natriuretic peptide (10,376 ± 1,996 vs 4,385 ± 1,266 ng/L, p = 0.06) and high-sensitive troponin T (43 ± 8.9 vs 36 ± 7.7 pg/L, p = 0.27) improvement. Thirty-day mortality was 0. Two patients developed a left atrial thrombus, 1 patient was on a ventilator for >12 hours, and 1 patient had significant access site bleeding. In conclusion, this study shows that percutaneous edge-to-edge mitral valve repair can be safely performed even in surgical high-risk patients with an STS score >15. At 1-month follow-up most patients showed persistent improvement in mitral regurgitation and a clinical benefit.
DOI:doi:10.1016/j.amjcard.2011.06.069
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.amjcard.2011.06.069
 DOI: https://doi.org/10.1016/j.amjcard.2011.06.069
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aged
 Cardiac Catheterization
 Critical Illness
 Echocardiography, Transesophageal
 Exercise Test
 Feasibility Studies
 Female
 Heart Valve Prosthesis
 Heart Valve Prosthesis Implantation
 Humans
 Male
 Mitral Valve Insufficiency
 Natriuretic Peptide, Brain
 Prospective Studies
 Severity of Illness Index
 Troponin T
K10plus-PPN:1828227315
Verknüpfungen:→ Zeitschrift

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