| |  Online-Ressource |
|---|
| Verfasst von: | Chunduri, Narendra Kumar [VerfasserIn]  |
|---|
| | Menges, Paul [VerfasserIn] |
|---|
| | Zhang, Xiaoxiao [VerfasserIn] |
|---|
| | Wieland, Angela [VerfasserIn] |
|---|
| | Gotsmann, Vincent Leon [VerfasserIn] |
|---|
| | Mardin, Balca [VerfasserIn] |
|---|
| | Buccitelli, Christopher [VerfasserIn] |
|---|
| | Korbel, Jan Oliver [VerfasserIn] |
|---|
| | Willmund, Felix [VerfasserIn] |
|---|
| | Kschischo, Maik [VerfasserIn] |
|---|
| | Raeschle, Markus [VerfasserIn] |
|---|
| | Storchova, Zuzana [VerfasserIn] |
|---|
| Titel: | Systems approaches identify the consequences of monosomy in somatic human cells |
|---|
| Verf.angabe: | Narendra Kumar Chunduri, Paul Menges, Xiaoxiao Zhang, Angela Wieland, Vincent Leon Gotsmann, Balca R. Mardin, Christopher Buccitelli, Jan O. Korbel, Felix Willmund, Maik Kschischo, Markus Raeschle, Zuzana Storchova |
|---|
| E-Jahr: | 2021 |
|---|
| Jahr: | 22 September 2021 |
|---|
| Umfang: | 17 S. |
|---|
| Fussnoten: | Gesehen am 03.01.2023 |
|---|
| Titel Quelle: | Enthalten in: Nature Communications |
|---|
| Ort Quelle: | [London] : Springer Nature, 2010 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 12(2021), Artikel-ID 5576, Seite 1-17 |
|---|
| ISSN Quelle: | 2041-1723 |
|---|
| Abstract: | Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we find that chromosome loss impairs proliferation and genomic stability. Transcriptome and proteome analysis demonstrates reduced expression of genes encoded on the monosomes, which is partially compensated in some cases. Monosomy also induces global changes in gene expression. Pathway enrichment analysis reveals that genes involved in ribosome biogenesis and translation are downregulated in all monosomic cells analyzed. Consistently, monosomies display defects in protein synthesis and ribosome assembly. We further show that monosomies are incompatible with p53 expression, likely due to defects in ribosome biogenesis. Accordingly, impaired ribosome biogenesis and p53 inactivation are associated with monosomy in cancer. Our systematic study of monosomy in human cells explains why monosomy is so detrimental and reveals the importance of p53 for monosomy occurrence in cancer. |
|---|
| DOI: | doi:10.1038/s41467-021-25288-x |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-021-25288-x |
|---|
| | Volltext: https://www.nature.com/articles/s41467-021-25288-x |
|---|
| | DOI: https://doi.org/10.1038/s41467-021-25288-x |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Cancer genomics |
|---|
| | Cell biology |
|---|
| | Genomic instability |
|---|
| | Proteomics |
|---|
| K10plus-PPN: | 1830218913 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Systems approaches identify the consequences of monosomy in somatic human cells / Chunduri, Narendra Kumar [VerfasserIn]; 22 September 2021 (Online-Ressource)
