Electrical storm reveals worse prognosis compared to myocardial infarction complicated by ventricular tachyarrhythmias in ICD recipients

• Verfasst von: Müller, Julian [VerfasserIn]
• Verfasst von: Behnes, Michael [VerfasserIn]
• Verfasst von: Schupp, Tobias [VerfasserIn]
• Verfasst von: Ellguth, Dominik [VerfasserIn]
• Verfasst von: Taton, Gabriel [VerfasserIn]
• Verfasst von: Reiser, Linda [VerfasserIn]
• Verfasst von: Engelke, Niko [VerfasserIn]
• Verfasst von: Borggrefe, Martin [VerfasserIn]
• Verfasst von: Reichelt, Thomas [VerfasserIn]
• Verfasst von: Kern-Bollow, Armin [VerfasserIn]
• Verfasst von: El-Battrawy, Ibrahim [VerfasserIn]
• Verfasst von: Weidner, Kathrin [VerfasserIn]
• Verfasst von: Kim, Seung‑Hyun [VerfasserIn]
• Verfasst von: Barth, Christian [VerfasserIn]
• Verfasst von: Ansari, Uzair [VerfasserIn]
• Verfasst von: Große Meininghaus, Dirk [VerfasserIn]
• Verfasst von: Akın, Muharrem [VerfasserIn]
• Verfasst von: Mashayekhi, Kambis [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Titel: Electrical storm reveals worse prognosis compared to myocardial infarction complicated by ventricular tachyarrhythmias in ICD recipients
• Verf.angabe: Julian Müller, Michael Behnes, Tobias Schupp, Dominik Ellguth, Gabriel Taton, Linda Reiser, Niko Engelke, Martin Borggrefe, Thomas Reichelt, Armin Bollow, Ibrahim El-Battrawy, Kathrin Weidner, Seung-Hyun Kim, Christian Barth, Uzair Ansari, Dirk Große Meininghaus, Muharrem Akin, Kambis Mashayekhi, Ibrahim Akin
• E-Jahr: 2021
• Jahr: 26 April 2021
• Umfang: 11 S.
• Fussnoten: Gesehen am 04.01.2023
• Titel Quelle: Enthalten in: Heart and vessels
• Ort Quelle: Tokyo : Springer, 1985
• Jahr Quelle: 2021
• Band/Heft Quelle: 36(2021), 11, Seite 1701-1711
• ISSN Quelle: 1615-2573
• DOI: doi:10.1007/s00380-021-01844-9
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1830320157
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Both acute myocardial infarction complicated by ventricular tachyarrhythmias (AMI-VTA) and electrical storm (ES) represent life-threatening clinical conditions. However, a direct comparison of both sub-groups regarding prognostic endpoints has never been investigated. All consecutive implantable cardioverter-defibrillator (ICD) recipients were included retrospectively from 2002 to 2016. Patients with ES apart from AMI (ES) were compared to patients with AMI accompanied by ventricular tachyarrhythmias (AMI-VTA). The primary endpoint was all-cause mortality at 3 years, secondary endpoints were in-hospital mortality, rehospitalization rates and major adverse cardiac event (MACE) at 3 years. A total of 198 consecutive ICD recipients were included (AMI-VTA: 56%; ST-segment elevation myocardial infarction (STEMI): 22%; non-ST-segment myocardial infarction (NSTEMI) 78%; ES: 44%). ES patients were older and had higher rates of severely reduced left ventricular ejection fraction (LVEF) < 35%. ES was associated with increased all-cause mortality at 3 years (37% vs. 19%; p = 0.001; hazard ratio [HR] = 2.242; 95% CI 2.291-3.894; p = 0.004) and with increased risk of first cardiac rehospitalization (44% vs. 12%; p = 0.001; HR = 4.694; 95% CI 2.498-8.823; p = 0.001). This worse prognosis of ES compared to AMI-VTA was still evident after multivariable adjustment (long-term all-cause mortality: HR = 2.504; 95% CI 1.093-5.739; p = 0.030; first cardiac rehospitalization: HR = 2.887; 95% CI 1.240-6.720; p = 0.014). In contrast, the rates of MACE (40% vs. 32%; p = 0.326) were comparable in both groups. At long-term follow-up of 3 years, ES was associated with higher rates of all-cause mortality and rehospitalization compared to patients with AMI-VTA.