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Verfasst von:Sirignano, Lea [VerfasserIn]   i
 Streit, Fabian [VerfasserIn]   i
 Frank, Josef [VerfasserIn]   i
 Zillich, Lea [VerfasserIn]   i
 Witt, Stephanie [VerfasserIn]   i
 Rietschel, Marcella [VerfasserIn]   i
 Foo, Jerome Clifford [VerfasserIn]   i
Titel:Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms
Verf.angabe:Lea Sirignano, Fabian Streit, Josef Frank, Lea Zillich, Stephanie H. Witt, Marcella Rietschel & Jerome C. Foo
E-Jahr:2022
Jahr:21 September 2022
Umfang:10 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 04.01.2023
Titel Quelle:Enthalten in: Scientific reports
Ort Quelle:[London] : Springer Nature, 2011
Jahr Quelle:2022
Band/Heft Quelle:12(2022) vom: Sept., Artikel-ID 15740, Seite 1-10
ISSN Quelle:2045-2322
Abstract:Major Depression and Bipolar Disorder Type I (BIP-I) and Type II (BIP-II), are characterized by depressed, manic, and hypomanic episodes in which specific changes of physical activity, circadian rhythm, and sleep are observed. It is known that genetic factors contribute to variation in mood disorders and biological rhythms, but unclear to what extent there is an overlap between their underlying genetics. In the present study, data from genome-wide association studies were used to examine the genetic relationship between mood disorders and biological rhythms. We tested the genetic correlation of depression, BIP-I, and BIP-II with physical activity (overall physical activity, moderate activity, sedentary behaviour), circadian rhythm (relative amplitude), and sleep features (sleep duration, daytime sleepiness). Genetic correlations of depression, BIP-I, and BIP-II with biological rhythms were compared to discover commonalities and differences. A gene-based analysis tested for associations of single genes and common circadian genes with mood disorders. Depression was negatively correlated with overall physical activity and positively with sedentary behaviour, while BIP-I showed associations in the opposite direction. Depression and BIP-II had negative correlations with relative amplitude. All mood disorders were positively correlated with daytime sleepiness. Overall, we observed both genetic commonalities and differences across mood disorders in their relationships with biological rhythms: depression and BIP-I differed the most, while BIP-II was in an intermediate position. Gene-based analysis suggested potential targets for further investigation. The present results suggest shared genetic underpinnings for the clinically observed associations between mood disorders and biological rhythms. Research considering possible joint mechanisms may offer avenues for improving disease detection and treatment.
DOI:doi:10.1038/s41598-022-19720-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/s41598-022-19720-5
 Volltext: https://www.nature.com/articles/s41598-022-19720-5
 DOI: https://doi.org/10.1038/s41598-022-19720-5
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Bipolar disorder
 Depression
 Genetics
 Genomic analysis
 Psychiatric disorders
K10plus-PPN:1830338218
Verknüpfungen:→ Zeitschrift

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