Nalmefene attenuates neural alcohol cue-reactivity in the ventral striatum and subjective alcohol craving in patients with alcohol use disorder

• Verfasst von: Karl, Damian [VerfasserIn]
• Verfasst von: Bumb, Jan Malte [VerfasserIn]
• Verfasst von: Bach, Patrick [VerfasserIn]
• Verfasst von: Dinter, Christina [VerfasserIn]
• Verfasst von: Koopmann, Anne [VerfasserIn]
• Verfasst von: Hermann, Derik [VerfasserIn]
• Verfasst von: Mann, Karl [VerfasserIn]
• Verfasst von: Kiefer, Falk [VerfasserIn]
• Verfasst von: Vollstädt-Klein, Sabine [VerfasserIn]
• Titel: Nalmefene attenuates neural alcohol cue-reactivity in the ventral striatum and subjective alcohol craving in patients with alcohol use disorder
• Verf.angabe: Damian Karl, J. Malte Bumb, Patrick Bach, Christina Dinter, Anne Koopmann, Derik Hermann, Karl Mann, Falk Kiefer, Sabine Vollstädt-Klein
• E-Jahr: 2021
• Jahr: 12 April 2021
• Umfang: 11 S.
• Fussnoten: Gesehen am 04.01.2023
• Titel Quelle: Enthalten in: Psychopharmacology
• Ort Quelle: Berlin : Springer, 1959
• Jahr Quelle: 2021
• Band/Heft Quelle: 238(2021), 8, Seite 2179-2189
• ISSN Quelle: 1432-2072
• DOI: doi:10.1007/s00213-021-05842-7
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Alcohol cue-reactivity
• Sach-SW: Controlled drinking
• Sach-SW: Harm reduction
• Sach-SW: Opioid receptors
• Sach-SW: Pharmacotherapy
• Sach-SW: Reduced drinking
• Sach-SW: Striatum
• K10plus-PPN: 1830359517
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Alcohol use disorder is a common and devastating mental illness for which satisfactory treatments are still lacking. Nalmefene, as an opioid receptor modulator, could pharmacologically support the reduction of drinking by reducing the (anticipated) rewarding effects of alcohol and expanding the range of treatment options. It has been hypothesized that nalmefene acts via an indirect modulation of the mesolimbic reward system. So far, only a few imaging findings on the neuronal response to nalmefene are available.