Age- and gender-related reference values of cardiac morphology and function in cardiovascular magnetic resonance

• Verfasst von: Riffel, Johannes [VerfasserIn]
• Verfasst von: Mayo, Rebecca [VerfasserIn]
• Verfasst von: Müller-Hennessen, Matthias [VerfasserIn]
• Verfasst von: Giannitsis, Evangelos [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: André, Florian [VerfasserIn]
• Titel: Age- and gender-related reference values of cardiac morphology and function in cardiovascular magnetic resonance
• Verf.angabe: Johannes H. Riffel, Rebecca Mayo, Matthias Mueller-Hennessen, Evangelos Giannitsis, Hugo A. Katus, Florian Andre
• E-Jahr: 2021
• Jahr: 22 January 2021
• Umfang: 13 S.
• Fussnoten: Gesehen am 11.01.2023
• Titel Quelle: Enthalten in: The international journal of cardiovascular imaging
• Ort Quelle: Dordrecht [u.a.] : Springer, 2001
• Jahr Quelle: 2021
• Band/Heft Quelle: 37(2021), 6, Seite 2011-2023
• ISSN Quelle: 1875-8312
• DOI: doi:10.1007/s10554-021-02160-z
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cardiovascular magnetic resonance
• Sach-SW: Left ventricular function
• Sach-SW: Morphology
• Sach-SW: Reference values
• K10plus-PPN: 1830817116
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Cardiovascular magnetic resonance (CMR) is the reference standard for the quantitative assessment of cardiac morphology and function. The aim of the study was to determine age- and gender-related reference values for cardiac morphology and function according to current recommendations. 454 healthy volunteers (235 men, median age 52.0 (44.0-59.0) years) underwent a standard CMR scan and were divided into six groups of nearly equal size with regard to sex (male, female) and age (21-47 years, 48-57 years, 58-84 years). Left ventricular end-diastolic (LV-EDV) and end-systolic (LV-ESV) volumes and LV mass (LV-M) were measured at end-diastole and end-systole in steady-state free precession series with including papillary muscles and trabecular tissue in the LV-M. Absolute and indexed volumetric parameters were significantly different between gender groups with higher values in men compared to women (all p < 0.001). Furthermore, a significant age-dependent decline could be observed for left ventricular and right ventricular volumes (all p < 0.001), while LV-M did not show differences between the different age-groups. Parameters of longitudinal function for the left and right ventricle were higher in female compared to male subjects with a significant age-dependent decline. We provided normal values for cardiac volumes, function, and mass derived in accordance with current guidelines from a large population of healthy subjects, which can be implemented in clinical routine as a standard of reference.